The Association Between Allostatic Load and Frailty Trajectories Among Adults Aged 50+ Years: Mediating Role of Physical Activity.

IF 1.4 4区医学 Q4 GERIATRICS & GERONTOLOGY Journal of Aging and Physical Activity Pub Date : 2023-08-31 Print Date: 2024-02-01 DOI:10.1123/japa.2022-0441

Kanglin Shi, Lingxiao He, Zeyun Zhang, Jianlin Lin, Xiaodong Chen, Xinyuan Du, Kewei Shi, Jinzhu Yang, Zaixing Shi, Ya Fang

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Abstract

Objectives: To identify frailty trajectories and examine its association with allostatic load (AL) and mediating effect of physical activity (PA).

Methods: This study included 8,082 adults from the English Longitudinal Study of Aging over Waves 4-9. AL was calculated by 14 biological indicators, and a 53-item frailty index was used to evaluate frailty. Frailty trajectories were classified by group-based trajectory modeling, and the mediated effect of PA was tested by causal mediation analysis.

Results: Four frailty trajectories were identified: "Robustness" (n = 4,437, 54.9%), "Incident prefrailty" (n = 2,061, 25.5%), "Prefrailty to frailty" (n = 1,136, 14.1%), and "Frailty to severe frailty" (n = 448, 5.5%). High baseline AL was associated with increased odds of "Incident prefrailty," "Prefrailty to frailty," and "Frailty to severe frailty" trajectories. PA demonstrated significant mediated effects in aforementioned associations.

Conclusions: AL is significantly associated with the onset and progression of frailty, and such associations are partially mediated by PA.

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50 岁以上成年人体内静态负荷与虚弱轨迹之间的关系：体育锻炼的中介作用

目的确定虚弱的轨迹，研究其与代谢负荷（AL）的关系以及体育锻炼（PA）的中介效应：这项研究包括英国老龄化纵向研究第 4-9 波的 8082 名成年人。AL由14项生物指标计算得出，53项虚弱指数用于评估虚弱程度。通过基于群体的轨迹建模对虚弱轨迹进行分类，并通过因果中介分析检验 PA 的中介效应：结果：确定了四种虚弱轨迹：结果：确定了四种虚弱轨迹："健壮"（n = 4 437，54.9%）、"发生虚弱前期"（n = 2 061，25.5%）、"虚弱前期至虚弱"（n = 1 136，14.1%）和 "虚弱至严重虚弱"（n = 448，5.5%）。高基线AL与 "发生虚弱前期"、"虚弱前期至虚弱 "和 "虚弱至严重虚弱 "的几率增加有关。PA在上述关联中表现出明显的中介效应：AL与虚弱的发生和发展有明显的关联，而这种关联部分是由PA介导的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Aging and Physical Activity 医学-老年医学

CiteScore

2.60

自引率

6.70%

发文量

105

审稿时长

>12 weeks

期刊介绍： The Journal of Aging and Physical Activity (JAPA) is a multidisciplinary journal that publishes peer-reviewed original research reports, scholarly reviews, and professional-application articles on the relationship between physical activity and the aging process. The journal encourages the submission of articles that can contribute to an understanding of (a) the impact of physical activity on physiological, psychological, and social aspects of older adults and (b) the effect of advancing age or the aging process on physical activity among older adults. In addition to publishing research reports and reviews, JAPA publishes articles that examine the development, implementation, and evaluation of physical activity programs among older adults. Articles from the biological, behavioral, and social sciences, as well as from fields such as medicine, clinical psychology, physical and recreational therapy, health, physical education, and recreation, are appropriate for the journal. Studies using animal models do not fit within our mission statement and should be submitted elsewhere.