Ji Hae Lee, HaeYong Kweon, Ji-Hyeon Oh, Seong-Gon Kim
{"title":"The optimal scaffold for silk sericin-based bone graft: collagen versus gelatin.","authors":"Ji Hae Lee, HaeYong Kweon, Ji-Hyeon Oh, Seong-Gon Kim","doi":"10.1186/s40902-022-00368-0","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Silk sericin is an active ingredient in bone grafts. However, the optimal scaffold for silk sericin has yet to be identified.</p><p><strong>Method: </strong>A critical-sized bone defect model in rat calvaria was used to evaluate bone regeneration. Silk sericin from Yeonnokjam, Bombyx mori, was incorporated into gelatin (group G, n = 6) and collagen (group C, n = 6). Bone regeneration was evaluated using micro-computed tomography (mCT) and histology.</p><p><strong>Results: </strong>Group C showed a larger bone volume than group G in the mCT analysis (P = 0.001). Histological analysis showed a larger area of bony defects in group G than in group C. The bone regeneration area in group C was significantly larger than that in group G (P = 0.003).</p><p><strong>Conclusion: </strong>Compared with gelatin, collagen shows better bone regeneration in silk sericin-based bone grafts.</p>","PeriodicalId":18357,"journal":{"name":"Maxillofacial Plastic and Reconstructive Surgery","volume":"45 1","pages":"2"},"PeriodicalIF":2.0000,"publicationDate":"2023-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826769/pdf/","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Maxillofacial Plastic and Reconstructive Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s40902-022-00368-0","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 1
Abstract
Background: Silk sericin is an active ingredient in bone grafts. However, the optimal scaffold for silk sericin has yet to be identified.
Method: A critical-sized bone defect model in rat calvaria was used to evaluate bone regeneration. Silk sericin from Yeonnokjam, Bombyx mori, was incorporated into gelatin (group G, n = 6) and collagen (group C, n = 6). Bone regeneration was evaluated using micro-computed tomography (mCT) and histology.
Results: Group C showed a larger bone volume than group G in the mCT analysis (P = 0.001). Histological analysis showed a larger area of bony defects in group G than in group C. The bone regeneration area in group C was significantly larger than that in group G (P = 0.003).
Conclusion: Compared with gelatin, collagen shows better bone regeneration in silk sericin-based bone grafts.
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