Cockroaches: a potential source of novel bioactive molecule(s) for the benefit of human health

IF 1.3 4区 农林科学 Q2 ENTOMOLOGY Applied Entomology and Zoology Pub Date : 2022-12-15 DOI:10.1007/s13355-022-00810-9
Ruqaiyyah Siddiqui, Yara Elmashak, Naveed Ahmed Khan
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引用次数: 5

Abstract

Cockroaches are one of the hardiest insects that have survived on this planet for millions of years. They thrive in unhygienic environments, are able to survive without food for up to 30 days, without air for around 45 min and being submerged under water for 30 min. Cockroaches are omnivorous and feed on a variety of foods, including cellulose and plastic, to name a few. It is intriguing that cockroaches are able to endure and flourish under conditions that are harmful to Homo sapiens. Given the importance of the gut microbiome on its’ host physiology, we postulate that the cockroach gut microbiome and/or its metabolites, may be contributing to their “hardiness”, which should be utilized for the discovery of biologically

active molecules for the benefit of human health. Herein, we discuss the biology, diet/habitat of cockroaches, composition of gut microbiome, cellular senescence, and resistance to infectious diseases and cancer. Furthermore, current knowledge of the genome and epigenome of these remarkable species is considered. Being one of the most successful and diverse insects, as well as their extensive use in traditional and Chinese medicine, the lysates/extracts and gut microbial metabolites of cockroaches may offer a worthy resource for novel bioactive molecule(s) of therapeutic potential for the benefit of human health and may be potentially used as probiotics.

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蟑螂:有益人类健康的新型生物活性分子的潜在来源
蟑螂是地球上生存了数百万年的最顽强的昆虫之一。它们在不卫生的环境中茁壮成长,在没有食物的情况下可以存活长达30天,在没有空气的情况下可以存活约45分钟,在水下可以存活30分钟。蟑螂是杂食性的,以各种食物为食,包括纤维素和塑料等。蟑螂能够在对智人有害的条件下生存和繁衍,这是很有趣的。鉴于肠道微生物组对宿主生理的重要性,我们假设蟑螂肠道微生物组和/或其代谢物可能有助于它们的“耐寒性”,这应该用于发现有益于人类健康的生物活性分子。在此,我们讨论了蟑螂的生物学、饮食/栖息地、肠道微生物组的组成、细胞衰老以及对传染病和癌症的抵抗力。此外,目前的知识基因组和表观基因组的这些显著的物种被考虑。蟑螂的裂解物/提取物和肠道微生物代谢物是最成功和最多样化的昆虫之一,在传统和中药中有着广泛的应用,为开发具有治疗潜力的新型生物活性分子提供了宝贵的资源,对人类健康有益,并有可能作为益生菌使用。
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来源期刊
CiteScore
2.70
自引率
7.70%
发文量
37
审稿时长
6-12 weeks
期刊介绍: Applied Entomology and Zoology publishes articles concerned with applied entomology, applied zoology, agricultural chemicals and pest control in English. Contributions of a basic and fundamental nature may be accepted at the discretion of the Editor. Manuscripts of original research papers, technical notes and reviews are accepted for consideration. No manuscript that has been published elsewhere will be accepted for publication.
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