Effect of Dopaminergic Therapy on Impulse Control Disorders in Patients With a Prolactinoma.

IF 1.3 4区 医学 Q4 BEHAVIORAL SCIENCES Cognitive and Behavioral Neurology Pub Date : 2023-03-01 DOI:10.1097/WNN.0000000000000320
Esin Ozdeniz Varan, Hakan Gurvit
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引用次数: 1

Abstract

Background: Studies have reported an increase in the incidence of impulse control disorders (ICDs) in patient groups treated with dopamine agonists (DAAs), especially in Parkinson disease (PD). However, very few studies have reported on ICDs in individuals with a prolactinoma who were treated with DAAs.

Objective: To see whether a DAA by itself causes ICDs in individuals with a prolactinoma by controlling the susceptibility to impulsivity by excluding individuals with other risk factors for ICDs.

Method: We compared the performance of 31 individuals with a prolactinoma receiving DAA therapy (DAA+) on various behavioral scales and the Iowa gambling task (IGT), a neuropsychological instrument that measures risky decision-making, with the performance of 20 individuals with a prolactinoma who were not on DAA therapy (DAA-) and 30 healthy controls (HC).

Results: There was no significant difference among the groups concerning performance on the Zuckerman Sensation Seeking Scale-V, Minnesota Impulse Disorders Interview, Barratt Impulsiveness Scale-11, or IGT. No correlation was found between the scores on these scales and the duration or dose of DAA in the DAA+ group. The incidence of ICDs was 25.8% in the DAA+ group, 15% in the DAA- group, and 16.7% in the HC. The differences among the groups did not reach statistical significance.

Conclusion: Individuals who are under treatment with low-dose, D 2 -selective DAAs for a prolactinoma do not face an increased risk for ICDs, especially when they are carefully screened for any psychiatric comorbidity that may also display impulsivity.

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多巴胺能治疗对泌乳素瘤患者冲动控制障碍的影响。
背景:研究报告称,在使用多巴胺激动剂(DAAs)治疗的患者组中,冲动控制障碍(ICD)的发生率增加,尤其是在帕金森病(PD)中。然而很少有研究报道用DAA治疗的泌乳素瘤患者的ICDs。目的:通过排除有ICDs其他危险因素的患者来控制冲动易感性,从而了解DAA本身是否会导致泌乳素瘤的ICDs。方法:我们比较了31名接受DAA治疗(DAA+)的泌乳素腺瘤患者的表现在各种行为量表和爱荷华赌博任务(IGT)(一种衡量风险决策的神经心理学工具)上,对20名未接受DAA治疗的泌乳素瘤患者和30名健康对照组(HC)的表现进行了比较,明尼苏达州冲动障碍访谈,Barratt冲动量表-11,或IGT。在DAA+组中,这些量表上的分数与DAA的持续时间或剂量之间没有发现相关性。ICDs的发生率在DAA+组为25.8%,在DAA-组为15%,在HC组为16.7%。各组之间的差异没有达到统计学意义。结论:接受低剂量、D2选择性DAAs治疗泌乳素瘤的个体不会面临增加的ICDs风险,尤其是当他们仔细筛查任何可能表现出冲动的精神共病时。
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来源期刊
CiteScore
2.40
自引率
7.10%
发文量
68
审稿时长
>12 weeks
期刊介绍: Cognitive and Behavioral Neurology (CBN) is a forum for advances in the neurologic understanding and possible treatment of human disorders that affect thinking, learning, memory, communication, and behavior. As an incubator for innovations in these fields, CBN helps transform theory into practice. The journal serves clinical research, patient care, education, and professional advancement. The journal welcomes contributions from neurology, cognitive neuroscience, neuropsychology, neuropsychiatry, and other relevant fields. The editors particularly encourage review articles (including reviews of clinical practice), experimental and observational case reports, instructional articles for interested students and professionals in other fields, and innovative articles that do not fit neatly into any category. Also welcome are therapeutic trials and other experimental and observational studies, brief reports, first-person accounts of neurologic experiences, position papers, hypotheses, opinion papers, commentaries, historical perspectives, and book reviews.
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