The Influence of Single Nucleotide Polymorphisms On Body Weight Trajectory After Bariatric Surgery: A Systematic Review.

IF 9.5 2区医学 Q1 ENDOCRINOLOGY & METABOLISM Current Obesity Reports Pub Date : 2023-09-01 Epub Date: 2023-06-30 DOI:10.1007/s13679-023-00514-3

Amélia Cristina Stival Duarte, Nara Rubia da Silva, Vivian Siqueira Santos Gonçalves, Flávia Campos Corgosinho, Kênia Mara Baiocchi de Carvalho, Maria Aderuza Horst

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Abstract

Purpose of review: To conduct a systematic review to summarize the results of studies on this subject and to identify whether single nucleotide polymorphisms (SNPs) are good prognostic markers for body weight trajectory after bariatric surgery.

Recent findings: A considerable number of events can influence the body weight trajectory after bariatric surgery, and in the post-genomic era, genetic factors have been explored. This study is registered with PROSPERO (CRD42021240903). SNPs positively associated with poor weight loss after bariatric surgery were rs17702901, rs9939609, rs1360780, rs1126535, rs1137101, rs17782313, rs490683, and rs659366. Alternatively, SNPs rs2229616, rs5282087, rs490683, rs9819506, rs4771122, rs9939609, rs4846567, rs9930506, rs3813929, rs738409, rs696217, rs660339, rs659366, rs6265, rs1801260, and rs2419621 predicted a higher weight loss after bariatric surgery. Six studies performed with a genetic risk score (GRS) model presented significant associations between GRS and outcomes following bariatric surgery. This systematic review shows that, different SNPs and genetic models could be good predictors for body weight trajectory after bariatric surgery. Based on the results of the selected studies for this Systematic Review is possible to select SNPs and metabolic pathways of interest for the GRS construction to predict the outcome of bariatric surgery to be applied in future studies.

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单核苷酸多态性对减肥手术后体重轨迹的影响：一项系统综述。

综述目的：进行系统综述，总结该受试者的研究结果，并确定单核苷酸多态性（SNPs）是否是减肥手术后体重轨迹的良好预后标志物。最近的发现：相当多的事件会影响减肥手术后的体重轨迹，在后基因组时代，遗传因素已经得到了探索。本研究已在PROSPERO注册（CRD42021240903）。与减肥手术后体重减轻不良呈正相关的SNPs为rs17702901、rs9939609、rs1360780、rs1126535、rs1137101、rs17782313、rs490683和rs659366。或者，SNPs rs2229616、rs5282087、rs490683、rs9819506、rs4771122、rs9939609、rs4846567、rs9930506、rs3813929、rs738409、rs696217、rs660339、rs659366、rs6265、rs1801260和rs2419621预测减肥手术后会有更高的体重减轻。使用遗传风险评分（GRS）模型进行的六项研究表明，GRS与减肥手术后的结果之间存在显著关联。这项系统综述表明，不同的SNPs和遗传模型可以很好地预测减肥手术后的体重轨迹。根据本系统综述所选研究的结果，可以选择GRS构建感兴趣的SNPs和代谢途径，以预测未来研究中应用的减肥手术的结果。

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来源期刊

Current Obesity Reports Medicine-General Medicine

CiteScore

16.40

自引率

1.10%

发文量

期刊介绍： The main objective of Current Obesity Reports is to provide expert review articles on recent advancements in the interdisciplinary field of obesity research. Our aim is to offer clear, insightful, and balanced contributions that will benefit all individuals involved in the treatment and prevention of obesity, as well as related conditions such as cardiovascular diseases, endocrine disorders, gynecological issues, cancer, mental health, respiratory complications, and rheumatological diseases. We strive to redefine the way knowledge is expressed and provide organized content for the benefit of our readership.