Nanobodies: A Game-Changer in Cell-Mediated Immunotherapy for Cancer

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2023-12-01 DOI:10.1016/j.slasd.2023.08.008
Mujahed I. Mustafa , Ahmed Mohammed
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Abstract

Nanobodies are small, single-domain antibodies that have emerged as a promising tool in cancer immunotherapy. These molecules can target specific antigens on cancer cells and trigger an immune response against them. In this mini-review article, we highlight the potential of nanobodies in cell-mediated immunotherapy for cancer treatment. We discuss the advantages of nanobodies over conventional antibodies, their ability to penetrate solid tumors, and their potential to enhance the efficacy of other immunotherapeutic agents. We also provide an overview of recent preclinical and clinical studies that have demonstrated the effectiveness of nanobody-based immunotherapy in various types of cancer.

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纳米抗体:改变癌症细胞介导免疫疗法的游戏规则
纳米抗体是一种小型单域抗体,已成为癌症免疫疗法中一种前景广阔的工具。这些分子可以靶向癌细胞上的特定抗原,并引发针对它们的免疫反应。在这篇微型综述文章中,我们将重点介绍纳米抗体在细胞介导的癌症免疫疗法中的潜力。我们讨论了纳米抗体相对于传统抗体的优势、纳米抗体穿透实体瘤的能力以及纳米抗体增强其他免疫治疗药物疗效的潜力。我们还概述了最近的临床前和临床研究,这些研究证明了基于纳米抗体的免疫疗法在各种癌症中的有效性。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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