{"title":"Alexey Olovnikov: theoretical biology beyond the margins.","authors":"Ivan A Olovnikov","doi":"10.1007/s10522-023-10061-y","DOIUrl":null,"url":null,"abstract":"<p><p>Alexey Olovnikov (1936-2022) is an author of the famous marginotomy hypothesis, where he recognized the DNA end replication problem and its role in cell aging. In this biographical note we celebrate the 50th anniversary of this theoretical discovery that later enjoyed a brilliant confirmation and gave rise to a new thriving field of molecular biology and gerontology. We also take a look at the evolution of ideas in Alexey Olovnikov's lifelong quest to uncover the molecular mechanisms of aging, exploring the reasons why he walked away from his initial conclusion about the key role of telomeres in aging, and built a new vast theoretical landscape that linked all stages of ontogenesis.</p>","PeriodicalId":8909,"journal":{"name":"Biogerontology","volume":" ","pages":"195-203"},"PeriodicalIF":4.4000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biogerontology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10522-023-10061-y","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/9/7 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Alexey Olovnikov (1936-2022) is an author of the famous marginotomy hypothesis, where he recognized the DNA end replication problem and its role in cell aging. In this biographical note we celebrate the 50th anniversary of this theoretical discovery that later enjoyed a brilliant confirmation and gave rise to a new thriving field of molecular biology and gerontology. We also take a look at the evolution of ideas in Alexey Olovnikov's lifelong quest to uncover the molecular mechanisms of aging, exploring the reasons why he walked away from his initial conclusion about the key role of telomeres in aging, and built a new vast theoretical landscape that linked all stages of ontogenesis.
期刊介绍：
The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments.
Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.
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