Effects of central FGF21 infusion on the glucose homeostasis in rats (brain-pancreas axis).

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM Archives of Physiology and Biochemistry Pub Date : 2024-10-01 Epub Date: 2023-01-16 DOI:10.1080/13813455.2023.2166964

Kevser Tanbek, Umit Yılmaz, Mehmet Gul, Ahmet Koç, Suleyman Sandal

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Abstract

Introduction: Glucose homeostasis is a physiological process mediated by a variety of hormones. Fibroblast growth factor (FGF) 21 is a protein expressed in the liver, adipose tissue, muscle and pancreas and exerts actions in multiple targets including adipose, liver, pancreas and hypothalamus. The aim of this study was to examine the possible involvement of FGF21 in pancreatic and central control of glucose by measuring reflective changes in the release of insulin and glucagon.

Methods: Thirty adult male Wistar Albino rats were divided; Control, PD + aCSF, PD + FGF21 groups (n = 10). Effects of intracerebroventricular (icv) FGF21 administration to pancreatic denervated (PD) rats. Agouti-related protein (AgRP), Pro-opiomelanocortin (POMC) levels and blood glucose homeostasis were investigated.

Results: Administration of FGF21 to 3rd ventricle increased food consumption but body weight didn't change significantly. AgRP level increased, pancreatic insulin levels increased, and glucagon level decreased.

Conclusion: Central FGF21 administration is effective in regulating blood glucose homeostasis by increasing the amount and efficiency of insulin and changing glucose use.

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输注中枢 FGF21 对大鼠葡萄糖稳态的影响（脑-胰腺轴）。

简介葡萄糖稳态是一个由多种激素介导的生理过程。成纤维细胞生长因子（FGF）21 是一种在肝脏、脂肪组织、肌肉和胰腺中表达的蛋白质，在脂肪、肝脏、胰腺和下丘脑等多个靶点发挥作用。本研究旨在通过测量胰岛素和胰高血糖素释放的反映性变化，研究 FGF21 可能参与胰腺和中枢对葡萄糖的控制：将 30 只成年雄性 Wistar Albino 大鼠分为对照组、PD + aCSF 组和 PD + FGF21 组（n = 10）。胰腺去神经化（PD）大鼠脑室内注射（icv）FGF21的效果。结果：结果：给第三脑室注射 FGF21 增加了食物消耗量，但体重没有显著变化。AgRP水平升高，胰岛素水平升高，胰高血糖素水平降低：结论：中枢注射 FGF21 可通过增加胰岛素的数量和效率以及改变葡萄糖的使用来有效调节血糖稳态。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.