Mixed Epithelial and Stromal Tumor: A Rare Renal Neoplasm-Case Report with Clinicopathologic Features and Review of the Literature.

IF 0.7 Q4 PATHOLOGY Case Reports in Pathology Pub Date : 2023-01-04 eCollection Date: 2023-01-01 DOI:10.1155/2023/3528377
Mukund Tinguria, Katherine Chorneyko
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Abstract

Mixed epithelial and stromal tumor (MEST) is a rare benign renal neoplasm composed of epithelial and stromal components. Here, we report a 61-year-old woman presenting with a left complex cystic renal mass. The lesion was found incidentally on ultrasound for abdominal discomfort. CT scan and MRI showed a 7.4 cm complex cystic lesion in the left kidney. The differential diagnoses included complex renal cyst and cystic renal cell carcinoma. Laparoscopic nephrectomy showed a large 7.5 cm multicystic tumor with thick and thin septae and smooth walled-cysts containing clear watery fluid. Histologic examination showed variable sized cysts lined by flattened, cuboidal to columnar epithelium with focal hobnailing. No significant cytologic atypia or mitoses were noted. The cyst lining epithelium was positive for CK7 and high molecular weight cytokeratin (34Be12). The stroma was positive for alpha smooth muscle actin, CD10, estrogen receptor, and progesterone receptor. This report contributes an additional case to our collective knowledge of these lesions and summarizes the literature around these rare neoplasms.

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上皮和间质混合瘤:罕见的肾肿瘤--临床病理特征和文献综述。
上皮和间质混合瘤(MEST)是一种罕见的肾脏良性肿瘤,由上皮和间质组成。在此,我们报告了一名 61 岁女性的左侧复杂囊性肾肿块病例。病变是在腹部不适的超声检查中偶然发现的。CT 扫描和 MRI 显示左肾有一个 7.4 厘米的复杂囊性病变。鉴别诊断包括复杂性肾囊肿和囊性肾细胞癌。腹腔镜肾切除术显示,这是一个 7.5 厘米大的多囊肿,囊壁厚薄不一,囊壁光滑,内含清水样液体。组织学检查显示,囊肿大小不一,内衬为扁平的立方体至柱状上皮,有局灶性梭形结构。未发现明显的细胞学不典型性或有丝分裂。囊肿内衬上皮的 CK7 和高分子量细胞角蛋白(34Be12)呈阳性。基质中的α平滑肌肌动蛋白、CD10、雌激素受体和孕酮受体均呈阳性。本报告为我们对这些病变的了解又增加了一例,并总结了有关这些罕见肿瘤的文献。
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来源期刊
自引率
0.00%
发文量
20
审稿时长
12 weeks
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