Event-related Potentials Corresponding to Decision-making Under Uncertain Conditions.

IF 1.3 4区 医学 Q4 BEHAVIORAL SCIENCES Cognitive and Behavioral Neurology Pub Date : 2023-09-01 DOI:10.1097/WNN.0000000000000346
Danielle C Farrar, Ronald J Killiany, Mark B Moss, Brandi Fink, Andrew E Budson
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Abstract

Background: Decision-making is essential to human functioning, and resolving uncertainty is an essential part of decision-making. Impaired decision-making is present in many pathological conditions, and identifying markers of decision-making under uncertainty will provide a measure of clinical impact in future studies of therapeutic intervention for impaired decision-making.

Objective: To describe EEG event-related potentials (ERPs) correlating with decision-making under uncertain conditions when compared with certain conditions.

Method: We used a novel card-matching task based on the Wisconsin Card Sorting Test to describe the neural correlates of uncertainty, as measured by EEG, in a group of 27 neurotypical individuals. We evaluated 500-ms intervals in the 2 seconds after card presentation to identify ERPs that are associated with maximal uncertainty compared with maximal certainty.

Results: After correcting for multiple comparisons, we identified an ERP in the 500-1000-ms time frame (certain > uncertain, max amplitude 12.73 µV, latency 914 ms) in the left posterior inferior region of the scalp. We also found a P300-like ERP in the left frontal and parietal regions in the 0-500-ms time frame when the individuals received correct versus incorrect feedback (incorrect feedback > correct feedback, max amplitude 1.625 µV, latency 339 ms).

Conclusion: We identified an ERP in the 500-1000-ms time frame (certain > uncertain) that may reflect the resolution of uncertainty, as well as a P300-like ERP when feedback is presented (incorrect feedback > correct feedback). These findings can be used in future studies to improve decision-making and resolve uncertainty on the described markers.

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不确定条件下决策的事件相关电位。
背景:决策对人类的功能至关重要,解决不确定性是决策的重要组成部分。决策受损存在于许多病理条件下,识别不确定性下决策的标记将为未来研究决策受损的治疗干预提供临床影响的衡量标准。目的:比较不确定条件下与确定条件下与决策相关的脑电图事件相关电位(erp)。方法:在威斯康星卡片分类测试的基础上,我们使用了一种新的卡片匹配任务来描述不确定性的神经相关性,通过脑电图测量,在一组27个神经典型个体中。我们在出示卡片后的2秒内评估500毫秒间隔,以识别与最大不确定性和最大确定性相关的erp。结果:经过多次比较校正后,我们在头皮左侧后下区确定了500-1000 ms时间范围内(确定>不确定,最大振幅12.73µV,潜伏期914 ms)的ERP。我们还发现,在0-500 ms的时间范围内,当个体接受正确反馈和错误反馈(错误反馈>正确反馈,最大振幅1.625µV,延迟339 ms)时,左额叶和顶叶区域出现了p300样的ERP。结论:我们发现了500-1000 ms时间框架内(确定>不确定)的ERP可以反映不确定性的解决,以及提供反馈时(错误反馈>正确反馈)的p300样ERP。这些发现可以用于未来的研究,以改善决策和解决所描述的标记的不确定性。
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来源期刊
CiteScore
2.40
自引率
7.10%
发文量
68
审稿时长
>12 weeks
期刊介绍: Cognitive and Behavioral Neurology (CBN) is a forum for advances in the neurologic understanding and possible treatment of human disorders that affect thinking, learning, memory, communication, and behavior. As an incubator for innovations in these fields, CBN helps transform theory into practice. The journal serves clinical research, patient care, education, and professional advancement. The journal welcomes contributions from neurology, cognitive neuroscience, neuropsychology, neuropsychiatry, and other relevant fields. The editors particularly encourage review articles (including reviews of clinical practice), experimental and observational case reports, instructional articles for interested students and professionals in other fields, and innovative articles that do not fit neatly into any category. Also welcome are therapeutic trials and other experimental and observational studies, brief reports, first-person accounts of neurologic experiences, position papers, hypotheses, opinion papers, commentaries, historical perspectives, and book reviews.
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