Monte Carlo Simulations Corroborate PET-Measured Discrepancies in Activity Assessments of Commercial 90Y Vials.

IF 9.1 1区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Journal of Nuclear Medicine Pub Date : 2023-09-01 DOI:10.2967/jnumed.123.265494
Lucrezia Auditore, Daniele Pistone, Antonio Italiano, Ernesto Amato, Silvano Gnesin
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引用次数: 2

Abstract

In a recent multicenter study, discrepancies between PET/CT-measured activity and vendor-calibrated activity for 90Y glass and resin microspheres were found. In the present work, the origin of these discrepancies was investigated by Monte Carlo (MC) simulations. Methods: Three vial configurations, containing 90Y-chloride, 90Y-labeled glass microspheres, and 90Y-labeled resin microspheres, were modeled with GAMOS, and the electric signal generated in an activity meter was simulated. Energy deposition was scored in the activity meter-active regions and converted into electric current per unit activity. Internal bremsstrahlung (IB) photons, always accompanying β-decay, were simulated in addition to 90Y decays. The electric current per source activity obtained for 90Y glass and resin microspheres, Iglass and Iresin, was compared in terms of relative percentage difference with that of 90Y-chloride ([Formula: see text] and [Formula: see text]) and each other (δ). The findings of this work were compared with the ones obtained through PET measurements in the multicenter study. Results: With the inclusion of IB photons as primary particles in MC simulations, the [Formula: see text] and [Formula: see text] results were 24.6% ± 3.9% and -15.0% ± 2.2%, respectively, whereas δ was 46.5% ± 1.9%, in very good agreement with the values reported in the multicenter study. Conclusion: The MC simulations performed in this study indicate that the discrepancies recently found between PET/CT-measured activity and vendor-calibrated activity for 90Y glass and resin microspheres can be attributed to differences in the geometry of the respective commercial vials and to the metrologic approach adopted for activity meter calibration with a 90Y-chloride liquid source. Furthermore, IB photons were shown to play a relevant role in determining the electric current in the activity meter.

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蒙特卡罗模拟证实了商用90Y小瓶活性评估中pet测量的差异。
在最近的一项多中心研究中,发现了PET/ ct测量的90Y玻璃和树脂微球活性与供应商校准的活性之间的差异。在本工作中,这些差异的起源是研究蒙特卡罗(MC)模拟。方法:采用GAMOS软件对90y -氯化物、90y标记玻璃微球和90y标记树脂微球三种小瓶构型进行建模,并对活度计产生的电信号进行模拟。能量沉积被记录在活动-活动区域,并转换成每单位活动的电流。除了90Y衰变外,还模拟了伴随β衰变的内部轫致辐射光子(IB)。比较了90Y玻璃微球和树脂微球(玻璃微球和树脂微球)的每源活度电流与90Y-氯离子微球([公式:见文]和[公式:见文])的相对百分比差异以及它们之间的相对百分比差异(δ)。本研究结果与多中心研究中PET测量结果进行了比较。结果:在MC模拟中,以IB光子为主要粒子,[公式:见文]和[公式:见文]的结果分别为24.6%±3.9%和-15.0%±2.2%,而δ为46.5%±1.9%,与多中心研究报告的值非常吻合。结论:本研究中进行的MC模拟表明,最近发现的PET/ ct测量的90Y玻璃微球和树脂微球的活性与供应商校准的活性之间的差异可归因于各自商业小瓶的几何形状差异以及采用90Y-氯化物液体源校准活度计所采用的计量方法。此外,IB光子被证明在确定活度计中的电流中起着相关的作用。
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来源期刊
Journal of Nuclear Medicine
Journal of Nuclear Medicine 医学-核医学
CiteScore
13.00
自引率
8.60%
发文量
340
审稿时长
1 months
期刊介绍: The Journal of Nuclear Medicine (JNM), self-published by the Society of Nuclear Medicine and Molecular Imaging (SNMMI), provides readers worldwide with clinical and basic science investigations, continuing education articles, reviews, employment opportunities, and updates on practice and research. In the 2022 Journal Citation Reports (released in June 2023), JNM ranked sixth in impact among 203 medical journals worldwide in the radiology, nuclear medicine, and medical imaging category.
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