An Overview of Ischemia-Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response.

Pub Date : 2022-12-01 DOI:10.5152/eurasianjmed.2022.22293
Mustafa Can Güler, Ayhan Tanyeli, Fazile Nur Ekinci Akdemir, Ersen Eraslan, Saime Özbek Şebin, Derya Güzel Erdoğan, Tuncer Nacar
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Abstract

Ischemia-reperfusion is a common health problem leading to several health conditions. The pathophysiology of ischemia-reperfusion is quite complex. Oxidative stress and inflammatory response contribute to ischemia-reperfusion mechanisms. Various parameters like proinflammatory cytokines, reactive oxygen species, occur during ischemia-reperfusion . There are several ways to investigate these values through biochemical and histopathologic findings. Malondialdehyde, glutathione, myeloperoxidase, superoxide dismutase, interleukin 6, interleukin 1β, tumor necrosis factor alpha, caspase-3, nuclear factor-kappa β, and LC3B (microtubu le-associated protein light chain 3, LC3) can be evaluated among these indicators.

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