Mustafa Can Güler, Ayhan Tanyeli, Fazile Nur Ekinci Akdemir, Ersen Eraslan, Saime Özbek Şebin, Derya Güzel Erdoğan, Tuncer Nacar
{"title":"An Overview of Ischemia-Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response.","authors":"Mustafa Can Güler, Ayhan Tanyeli, Fazile Nur Ekinci Akdemir, Ersen Eraslan, Saime Özbek Şebin, Derya Güzel Erdoğan, Tuncer Nacar","doi":"10.5152/eurasianjmed.2022.22293","DOIUrl":null,"url":null,"abstract":"<p><p>Ischemia-reperfusion is a common health problem leading to several health conditions. The pathophysiology of ischemia-reperfusion is quite complex. Oxidative stress and inflammatory response contribute to ischemia-reperfusion mechanisms. Various parameters like proinflammatory cytokines, reactive oxygen species, occur during ischemia-reperfusion . There are several ways to investigate these values through biochemical and histopathologic findings. Malondialdehyde, glutathione, myeloperoxidase, superoxide dismutase, interleukin 6, interleukin 1β, tumor necrosis factor alpha, caspase-3, nuclear factor-kappa β, and LC3B (microtubu le-associated protein light chain 3, LC3) can be evaluated among these indicators.</p>","PeriodicalId":74999,"journal":{"name":"","volume":"54 Suppl1","pages":"62-65"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11163358/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5152/eurasianjmed.2022.22293","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Ischemia-reperfusion is a common health problem leading to several health conditions. The pathophysiology of ischemia-reperfusion is quite complex. Oxidative stress and inflammatory response contribute to ischemia-reperfusion mechanisms. Various parameters like proinflammatory cytokines, reactive oxygen species, occur during ischemia-reperfusion . There are several ways to investigate these values through biochemical and histopathologic findings. Malondialdehyde, glutathione, myeloperoxidase, superoxide dismutase, interleukin 6, interleukin 1β, tumor necrosis factor alpha, caspase-3, nuclear factor-kappa β, and LC3B (microtubu le-associated protein light chain 3, LC3) can be evaluated among these indicators.