Antiviral Potential of Melissa officinalis L.: A Literature Review.

IF 2.3 Q3 NUTRITION & DIETETICS Nutrition and Metabolic Insights Pub Date : 2023-01-12 eCollection Date: 2023-01-01 DOI:10.1177/11786388221146683

Amirhossein Behzadi, Sadegh Imani, Niloofar Deravi, Zahra Mohammad Taheri, Fatemeh Mohammadian, Zahra Moraveji, Sepideh Shavysi, Motahareh Mostafaloo, Fateme Soleimani Hadidi, Sepehr Nanbakhsh, Sepehr Olangian-Tehrani, Mohammad Hesam Marabi, Parisa Behshood, Mohadeseh Poudineh, Ali Kheirandish, Kimia Keylani, Pooya Behfarnia

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Abstract

The use of synthetic drugs has increased in recent years; however, herbal medicine is yet more trusted among a huge population worldwide; This could be due to minimal side effects, affordable prices, and traditional beliefs. Lemongrass (Melissa officinalis) has been widely used for reducing stress and anxiety, increasing appetite and sleep, reducing pain, healing wounds, and treating poisonous insect bites and bee stings for a long time. Today, research has shown that this plant can also fight viruses including Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Herpes Simplex Virus (HSV), and Human Immunodeficiency Virus (HIV) through various mechanisms such as inhibiting HSV-1 from binding to host cell, inhibiting HSV-1 replication during the post-adsorption or inhibiting main protease and spike protein of SARS-CoV-2, furthermore, be effective in treating related diseases. This Review investigated the antiviral properties of Melissa officinalis and its effect on viral diseases. More in vitro and in vivo studies are needed to determine Melissa officinaliss underlying mechanism, and more randomized controlled trials should be done to identify its effect in humans. Also, due to the usefulness and lack of side effects, it can be used more as a complementary medicine.

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Melissa officinalis L.的抗病毒潜力：文献综述。

近年来，合成药物的使用越来越多；然而，草药却更受全世界广大民众的信赖；这可能是因为草药的副作用极小、价格实惠，而且具有传统观念。长期以来，柠檬草（Melissa officinalis）一直被广泛用于减轻压力和焦虑、增进食欲和睡眠、减轻疼痛、愈合伤口以及治疗毒虫叮咬和蜜蜂蛰伤。如今，研究表明这种植物也能通过各种机制抗病毒，包括严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）、单纯疱疹病毒（HSV）和人类免疫缺陷病毒（HIV），如抑制 HSV-1 与宿主细胞结合、抑制 HSV-1 在吸附后的复制或抑制 SARS-CoV-2 的主要蛋白酶和尖峰蛋白，并能有效治疗相关疾病。本综述研究了香蜂草的抗病毒特性及其对病毒性疾病的影响。要确定 Melissa officinaliss 的内在机制，还需要进行更多的体外和体内研究，并应进行更多的随机对照试验，以确定其对人体的作用。此外，由于其有用性和无副作用，可更多地将其用作辅助药物。

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来源期刊

Nutrition and Metabolic Insights NUTRITION & DIETETICS-

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： Nutrition and Metabolic Insights is a peer-reviewed, open-access online journal focusing on all aspects of nutrition and metabolism. This encompasses nutrition, including the biochemistry of metabolism, exercise and associated physical processes and also includes clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes. It includes research at the molecular, cellular and organismal levels. This journal welcomes new manuscripts for peer review on the following topics: Nutrition, including the biochemistry of metabolism, Exercise and associated physical processes, Clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes, Research at the molecular, cellular and organismal levels, Other areas of interest include gene-nutrient interactions, the effects of hormones, models of metabolic function, macronutrient interactions, outcomes of changes in diet, and pathophysiology.