Potential association of HSPD1 with dysregulations in ribosome biogenesis and immune cell infiltration in lung adenocarcinoma: An integrated bioinformatic approach.

IF 2.2 4区 医学 Q3 ONCOLOGY Cancer Biomarkers Pub Date : 2024-01-01 DOI:10.3233/CBM-220442
Siripat Aluksanasuwan, Keerakarn Somsuan, Jatuporn Ngoenkam, Somchai Chutipongtanate, Sutatip Pongcharoen
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Abstract

Background: Lung adenocarcinoma (LUAD) is a major histological subtype of lung cancer with a high mortality rate worldwide. Heat shock protein family D member 1 (HSPD1, also known as HSP60) is reported to be increased in tumor tissues of lung cancer patients compared with healthy control tissues.

Objective: We aimed to investigate the roles of HSPD1 in prognosis, carcinogenesis, and immune infiltration in LUAD using an integrative bioinformatic analysis.

Methods: HSPD1 expression in LUAD was investigated in several transcriptome-based and protein databases. Survival analysis was performed using the KM plotter and OSluca databases, while prognostic significance was independently confirmed through univariate and multivariate analyses. Integrative gene interaction network and enrichment analyses of HSPD1-correlated genes were performed to investigate the roles of HSPD1 in LUAD carcinogenesis. TIMER and TISIDB were used to analyze correlation between HSPD1 expression and immune cell infiltration.

Results: The mRNA and protein expressions of HSPD1 were higher in LUAD compared with normal tissues. High HSPD1 expression was associated with male gender and LUAD with advanced stages. High HSPD1 expression was an independent prognostic factor associated with poor survival in LUAD patients. HSPD1-correlated genes with prognostic impact were mainly involved in aberrant ribosome biogenesis, while LUAD patients with high HSPD1 expression had low tumor infiltrations of activated and immature B cells and CD4+ T cells.

Conclusions: HSPD1 may play a role in the regulation of ribosome biogenesis and B cell-mediated immunity in LUAD. It could serve as a predictive biomarker for prognosis and immunotherapy response in LUAD.

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HSPD1 与肺腺癌核糖体生物生成和免疫细胞浸润失调的潜在关联:一种综合生物信息学方法。
背景:肺腺癌(LUAD)是肺癌的一个主要组织学亚型,在全球范围内具有很高的死亡率。据报道,与健康对照组织相比,肺癌患者肿瘤组织中的热休克蛋白家族 D 成员 1(HSPD1,又称 HSP60)含量增高:方法:在多个基于转录组和蛋白质的数据库中调查 HSPD1 在 LUAD 中的表达。利用KM plotter和OSluca数据库进行了生存分析,并通过单变量和多变量分析独立确认了预后意义。对HSPD1相关基因进行了整合基因相互作用网络和富集分析,以研究HSPD1在LUAD癌变中的作用。利用TIMER和TISIDB分析HSPD1表达与免疫细胞浸润的相关性:结果:与正常组织相比,HSPD1在LUAD中的mRNA和蛋白表达量更高。HSPD1的高表达与男性性别和LUAD晚期有关。HSPD1的高表达是LUAD患者生存率低的一个独立预后因素。对预后有影响的HSPD1相关基因主要参与异常核糖体生物生成,而HSPD1高表达的LUAD患者肿瘤浸润的活化和未成熟B细胞及CD4+ T细胞较少:结论:HSPD1可能在LUAD的核糖体生物发生和B细胞介导的免疫调节中发挥作用。结论:HSPD1可能在LUAD的核糖体生物发生和B细胞介导的免疫中发挥调节作用,可作为LUAD预后和免疫治疗反应的预测性生物标志物。
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来源期刊
Cancer Biomarkers
Cancer Biomarkers ONCOLOGY-
CiteScore
5.20
自引率
3.20%
发文量
195
审稿时长
3 months
期刊介绍: Concentrating on molecular biomarkers in cancer research, Cancer Biomarkers publishes original research findings (and reviews solicited by the editor) on the subject of the identification of markers associated with the disease processes whether or not they are an integral part of the pathological lesion. The disease markers may include, but are not limited to, genomic, epigenomic, proteomics, cellular and morphologic, and genetic factors predisposing to the disease or indicating the occurrence of the disease. Manuscripts on these factors or biomarkers, either in altered forms, abnormal concentrations or with abnormal tissue distribution leading to disease causation will be accepted.
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