Novel therapeutic avenues for kisspeptin

IF 4 3区 医学 Q1 PHARMACOLOGY & PHARMACY Current Opinion in Pharmacology Pub Date : 2022-12-01 DOI:10.1016/j.coph.2022.102319
Jovanna Tsoutsouki , Ali Abbara , Waljit Dhillo
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引用次数: 5

Abstract

Kisspeptin is a hypothalamic neuropeptide that acts via the hypothalamus to stimulate hypothalamic gonadotrophin-releasing hormone secretion and downstream gonadotrophin release. In health, kisspeptin induces normal puberty and modulates ovulation in healthy women. Hypothalamic kisspeptin expression is reduced in several functional reproductive disorders; thus, treating such conditions with kisspeptin is conceptually attractive. Recent studies have demonstrated that kisspeptin can induce a more physiological degree of oocyte maturation during in vitro fertilisation treatment that can reduce the risk of potentially life-threatening complications such as ovarian hyperstimulation syndrome seen with human chorionic gonadotrophin. Furthermore, chronic use of kisspeptin could potentially restore reproductive health in females with hypothalamic amenorrhoea, treat hyposexual drive disorder in otherwise healthy males and has potential indications in polycystic ovary syndrome, osteoporosis and metabolic dysfunction-associated fatty liver disease. Finally, kisspeptin analogues could potentially overcome some of the pharmacological challenges associated with the natural forms of kisspeptin such as short duration of action and development of tachyphylaxis.

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kisspeptin的新治疗途径
Kisspeptin是一种下丘脑神经肽,通过下丘脑刺激下丘脑促性腺激素释放激素分泌和下游促性腺激素释放。在健康方面,kisspeptin可诱导正常的青春期并调节健康女性的排卵。下丘脑kisspeptin表达在几种功能性生殖障碍中降低;因此,用kisspeptin治疗这些疾病在概念上是有吸引力的。最近的研究表明,在体外受精治疗过程中,kisspeptin可以诱导更生理程度的卵母细胞成熟,从而降低潜在危及生命的并发症的风险,如人绒毛膜促性腺激素引起的卵巢过度刺激综合征。此外,长期使用kisspeptin可以潜在地恢复下丘脑闭经女性的生殖健康,治疗其他健康男性的性欲减退,并在多囊卵巢综合征、骨质疏松症和代谢功能障碍相关的脂肪肝疾病中具有潜在的适应症。最后,kisspeptin类似物可能潜在地克服一些与自然形式的kisspeptin相关的药理学挑战,如作用时间短和快速反应的发展。
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来源期刊
CiteScore
8.80
自引率
2.50%
发文量
131
审稿时长
4-8 weeks
期刊介绍: Current Opinion in Pharmacology (COPHAR) publishes authoritative, comprehensive, and systematic reviews. COPHAR helps specialists keep up to date with a clear and readable synthesis on current advances in pharmacology and drug discovery. Expert authors annotate the most interesting papers from the expanding volume of information published today, saving valuable time and giving the reader insight on areas of importance.
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