The prevalence of low muscle mass associated with obesity in the USA.

IF 5.3 2区医学 Q2 CELL BIOLOGY Skeletal Muscle Pub Date : 2022-12-21 DOI:10.1186/s13395-022-00309-5

Dana J Murdock, Ning Wu, Joseph S Grimsby, Roberto A Calle, Stephen Donahue, David J Glass, Mark W Sleeman, Robert J Sanchez

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引用次数: 3

Abstract

Background: Sarcopenia is defined as age-related low muscle mass and function, and can also describe the loss of muscle mass in certain medical conditions, such as sarcopenic obesity. Sarcopenic obesity describes loss of muscle and function in obese individuals; however, as sarcopenia is an age-related condition and obesity can occur in any age group, a more accurate term is obesity with low lean muscle mass (OLLMM). Given limited data on OLLMM (particularly in those aged < 65 years), the purpose of this study was to estimate the prevalence of OLLMM in adults aged ≥ 20 years in the USA.

Methods: Data from the National Health and Nutrition Examination Survey (NHANES) 2017-2018 and 1999-2006 were used. OLLMM was defined as an appendicular lean mass, adjusted for body mass index (BMI), cut-off point < 0.789 for males and < 0.512 for females, measured by dual-energy X-ray absorptiometry (DXA). DXA was only measured in individuals 20-59 years old in NHANES 2017-2018; we therefore utilized logistic regression models to predict OLLMM from NHANES 1999-2006 for those aged ≥ 60 years. The prevalence of OLLMM was estimated overall, and by sex, age, race/ethnicity, and clinical subgroup (high BMI, prediabetes, type 2 diabetes mellitus [T2DM], non-alcoholic fatty liver disease [NAFLD] with fibrosis, or post-bariatric surgery). Prevalence estimates were extrapolated to the USA population using NHANES sampling weights.

Results: We estimated that, during 2017-2018, 28.7 million or 15.9% of the USA population had OLLMM. The prevalence of OLLMM was greater in older individuals (8.1%, aged 20-59 years vs 28.3%, aged ≥ 60 years), highest (66.6%) in Mexican-American females aged ≥ 60 years, and lowest (2.6%) in non-Hispanic Black males aged 20-59 years. There was a higher prevalence of OLLMM in adults with prediabetes (19.7%), T2DM (34.5%), NAFLD with fibrosis (25.4%), or post-bariatric surgery (21.8%), compared with those without each condition.

Conclusions: Overall, the burden of OLLMM in the USA is substantial, affecting almost 30 million adults. The prevalence of OLLMM increased with age, and among those with prediabetes, T2DM, NAFLD with fibrosis, or post-bariatric surgery. A unified definition of OLLMM will aid diagnosis and treatment strategies.

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在美国，低肌肉量的流行与肥胖有关。

背景:肌肉减少症被定义为与年龄相关的肌肉质量和功能降低，也可以描述某些医疗条件下肌肉质量的减少，如肌肉减少性肥胖。肌肉减少性肥胖描述的是肥胖个体肌肉和功能的丧失;然而，由于肌肉减少症是一种与年龄有关的疾病，肥胖可以发生在任何年龄组，因此更准确的术语是低瘦肌肉量肥胖(OLLMM)。考虑到有关OLLMM的数据有限(尤其是年龄< 65岁的人群)，本研究的目的是估计美国年龄≥20岁的成年人OLLMM的患病率。方法:使用2017-2018年和1999-2006年国家健康与营养检查调查(NHANES)的数据。通过双能x线吸收仪(DXA)测量，经体重指数(BMI)调整后，OLLMM定义为阑尾瘦体重，截断点男性< 0.789，女性< 0.512。在NHANES 2017-2018中，仅在20-59岁的个体中测量DXA;因此，我们使用逻辑回归模型来预测NHANES 1999-2006中年龄≥60岁的OLLMM。总体估计了OLLMM的患病率，并按性别、年龄、种族/民族和临床亚组(高BMI、前驱糖尿病、2型糖尿病[T2DM]、非酒精性脂肪肝[NAFLD]合并纤维化或减肥手术后)进行了评估。患病率估计外推到美国人口使用NHANES抽样权重。结果:我们估计，在2017-2018年期间，2870万人或15.9%的美国人口患有OLLMM。OLLMM的患病率在老年人中更高(8.1%，年龄在20-59岁，28.3%，年龄≥60岁)，在年龄≥60岁的墨西哥裔美国女性中最高(66.6%)，在20-59岁的非西班牙裔黑人男性中最低(2.6%)。与没有这两种疾病的成年人相比，患有糖尿病前期(19.7%)、2型糖尿病(34.5%)、NAFLD合并纤维化(25.4%)或减肥手术后(21.8%)的成年人中OLLMM的患病率更高。结论:总体而言，在美国，OLLMM的负担是巨大的，影响了近3000万成年人。随着年龄的增长，在糖尿病前期、2型糖尿病、NAFLD合并纤维化或减肥手术后患者中，OLLMM的患病率增加。OLLMM的统一定义将有助于诊断和治疗策略。

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来源期刊

Skeletal Muscle CELL BIOLOGY-

CiteScore

9.10

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： The only open access journal in its field, Skeletal Muscle publishes novel, cutting-edge research and technological advancements that investigate the molecular mechanisms underlying the biology of skeletal muscle. Reflecting the breadth of research in this area, the journal welcomes manuscripts about the development, metabolism, the regulation of mass and function, aging, degeneration, dystrophy and regeneration of skeletal muscle, with an emphasis on understanding adult skeletal muscle, its maintenance, and its interactions with non-muscle cell types and regulatory modulators. Main areas of interest include: -differentiation of skeletal muscle- atrophy and hypertrophy of skeletal muscle- aging of skeletal muscle- regeneration and degeneration of skeletal muscle- biology of satellite and satellite-like cells- dystrophic degeneration of skeletal muscle- energy and glucose homeostasis in skeletal muscle- non-dystrophic genetic diseases of skeletal muscle, such as Spinal Muscular Atrophy and myopathies- maintenance of neuromuscular junctions- roles of ryanodine receptors and calcium signaling in skeletal muscle- roles of nuclear receptors in skeletal muscle- roles of GPCRs and GPCR signaling in skeletal muscle- other relevant aspects of skeletal muscle biology. In addition, articles on translational clinical studies that address molecular and cellular mechanisms of skeletal muscle will be published. Case reports are also encouraged for submission. Skeletal Muscle reflects the breadth of research on skeletal muscle and bridges gaps between diverse areas of science for example cardiac cell biology and neurobiology, which share common features with respect to cell differentiation, excitatory membranes, cell-cell communication, and maintenance. Suitable articles are model and mechanism-driven, and apply statistical principles where appropriate; purely descriptive studies are of lesser interest.