The role and application of transcriptional repressors in cancer treatment

IF 6.9 3区 医学 Q1 CHEMISTRY, MEDICINAL Archives of Pharmacal Research Pub Date : 2023-01-16 DOI:10.1007/s12272-023-01427-4
Miso Park, Keon Wook Kang, Ji Won Kim
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引用次数: 1

Abstract

Gene expression is modulated through the integration of many regulatory elements and their associated transcription factors (TFs). TFs bind to specific DNA sequences and either activate or repress transcriptional activity. Through decades of research, it has been established that aberrant expression or functional abnormalities of TFs can lead to uncontrolled cell division and the development of cancer. Initial studies on transcriptional regulation in cancer have focused on TFs as transcriptional activators. However, recent studies have demonstrated several different mechanisms of transcriptional repression in cancer, which could be potential therapeutic targets for the development of specific anti-cancer agents. In the first section of this review, “Emerging roles of transcriptional repressors in cancer development,” we summarize the current understanding of transcriptional repressors and their involvement in the molecular processes of cancer progression. In the subsequent section, “Therapeutic applications,” we provide an updated overview of the available therapeutic targets for drug discovery and discuss the new frontier of such applications.

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转录抑制因子在癌症治疗中的作用及应用
基因表达是通过整合许多调控元件及其相关转录因子(TF)来调节的。TF与特定的DNA序列结合,并激活或抑制转录活性。经过几十年的研究,已经确定了TFs的异常表达或功能异常会导致不受控制的细胞分裂和癌症的发展。癌症转录调控的初步研究主要集中在转录因子作为转录激活因子。然而,最近的研究已经证明了癌症转录抑制的几种不同机制,这可能是开发特定抗癌药物的潜在治疗靶点。在这篇综述的第一部分“转录抑制因子在癌症发展中的新作用”中,我们总结了目前对转录抑制因子及其参与癌症进展分子过程的理解。在接下来的“治疗应用”一节中,我们提供了药物发现的可用治疗靶点的最新概述,并讨论了此类应用的新前沿。
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来源期刊
CiteScore
13.40
自引率
9.00%
发文量
48
审稿时长
3.3 months
期刊介绍: Archives of Pharmacal Research is the official journal of the Pharmaceutical Society of Korea and has been published since 1976. Archives of Pharmacal Research is an interdisciplinary journal devoted to the publication of original scientific research papers and reviews in the fields of drug discovery, drug development, and drug actions with a view to providing fundamental and novel information on drugs and drug candidates.
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