Contribution of APOA5, APOC3, CETP, ABCA1 and SIK3 genetic variants to hypertriglyceridemia development in Mexican HIV-patients receiving antiretroviral therapy.

IF 1.7 3区 医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Pharmacogenetics and genomics Pub Date : 2022-04-01 DOI:10.1097/FPC.0000000000000458
Jonathan Saúl Bautista-Martínez, José Antonio Mata-Marín, Jorge Luis Sandoval-Ramírez, Alberto Chaparro-Sánchez, Bulmaro Manjarrez-Téllez, Luis Antonio Uribe-Noguez, Jesús Gaytán-Martínez, Mireya Núñez-Armendáriz, Arcenio Cruz-Sánchez, Nohemí Núñez-Rodríguez, Martínez-Abarca Iván, Georgina Selene Morales-González, Juan Pablo Álvarez-Mendoza, Edgar Pérez-Barragán, Jussara Ríos-De Los Ríos, Gerson Gabriel Contreras-Chávez, Denisse Marielle Tapia-Magallanes, Rosa Maria Ribas-Aparicio, Mónica Díaz-López, Azucena Olivares-Labastida, Alejandro Gómez-Delgado, Javier Torres, Antonio Miranda-Duarte, Juan C Zenteno, Ericka Nelly Pompa-Mera
{"title":"Contribution of APOA5, APOC3, CETP, ABCA1 and SIK3 genetic variants to hypertriglyceridemia development in Mexican HIV-patients receiving antiretroviral therapy.","authors":"Jonathan Saúl Bautista-Martínez,&nbsp;José Antonio Mata-Marín,&nbsp;Jorge Luis Sandoval-Ramírez,&nbsp;Alberto Chaparro-Sánchez,&nbsp;Bulmaro Manjarrez-Téllez,&nbsp;Luis Antonio Uribe-Noguez,&nbsp;Jesús Gaytán-Martínez,&nbsp;Mireya Núñez-Armendáriz,&nbsp;Arcenio Cruz-Sánchez,&nbsp;Nohemí Núñez-Rodríguez,&nbsp;Martínez-Abarca Iván,&nbsp;Georgina Selene Morales-González,&nbsp;Juan Pablo Álvarez-Mendoza,&nbsp;Edgar Pérez-Barragán,&nbsp;Jussara Ríos-De Los Ríos,&nbsp;Gerson Gabriel Contreras-Chávez,&nbsp;Denisse Marielle Tapia-Magallanes,&nbsp;Rosa Maria Ribas-Aparicio,&nbsp;Mónica Díaz-López,&nbsp;Azucena Olivares-Labastida,&nbsp;Alejandro Gómez-Delgado,&nbsp;Javier Torres,&nbsp;Antonio Miranda-Duarte,&nbsp;Juan C Zenteno,&nbsp;Ericka Nelly Pompa-Mera","doi":"10.1097/FPC.0000000000000458","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the impact of single nucleotide polymorphisms (SNPs) from APOA5, APOC3, CETP, ATP binding cassette transporter A1 and SIK3 genes in the development of hypertriglyceridemia in HIV patients under antiretroviral therapy.</p><p><strong>Material and methods: </strong>A case-control study was developed. Leukocytic genomic DNA was extracted and genotyping for SNPs rs662799, rs964184, rs5128, rs2854116, rs2854117, rs3764261, rs4149310, rs4149267 and rs139961185 was performed by real time-PCR using TaqMan allelic discrimination assays, in Mexican mestizo patients with HIV infection, with hypertriglyceridemia (>1.7 mmol/L) under antiretroviral therapy. Genetic variants were also investigated in a control group of normolipidemic HIV patients (≤ 1.7 mmol/L). Haplotypes and gene interactions were analyzed.</p><p><strong>Results: </strong>A total of 602 HIV patients were genotyped (316 cases and 286 controls). Age and antiretroviral regimen based on protease inhibitors were associated with hypertriglyceridemia (P = 0.0001 and P = 0.0002. respectively). SNP rs964184 GG genotype in APOA5 gene exhibited the highest association with hypertriglyceridemia risk (OR, 3.2, 95% CI, 1.7-5.8, P = 0.0001); followed by SNP rs139961185 in SIK3 gene (OR = 2.3; (95% CI, 1.1-4.8; P = 0.03 for AA vs. AG genotype; and APOC3 rs5128 GG genotype, (OR, 2.2; 95% CI, 1.1-4.9; P = 0.04) under codominant models. These associations were maintained in the adjusted analysis by age and protease inhibitors based antiretroviral regimens.</p><p><strong>Conclusions: </strong>This study reveals an association between rs964184 in APOA5; rs5128 in APOC3 and rs139961185 in SIK3 and high triglyceride concentrations in Mexican HIV-patients receiving protease inhibitors. These genetic factors may influence the adverse effects related to antiretroviral therapy.</p>","PeriodicalId":19763,"journal":{"name":"Pharmacogenetics and genomics","volume":"32 3","pages":"101-110"},"PeriodicalIF":1.7000,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacogenetics and genomics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/FPC.0000000000000458","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 2

Abstract

Objective: To investigate the impact of single nucleotide polymorphisms (SNPs) from APOA5, APOC3, CETP, ATP binding cassette transporter A1 and SIK3 genes in the development of hypertriglyceridemia in HIV patients under antiretroviral therapy.

Material and methods: A case-control study was developed. Leukocytic genomic DNA was extracted and genotyping for SNPs rs662799, rs964184, rs5128, rs2854116, rs2854117, rs3764261, rs4149310, rs4149267 and rs139961185 was performed by real time-PCR using TaqMan allelic discrimination assays, in Mexican mestizo patients with HIV infection, with hypertriglyceridemia (>1.7 mmol/L) under antiretroviral therapy. Genetic variants were also investigated in a control group of normolipidemic HIV patients (≤ 1.7 mmol/L). Haplotypes and gene interactions were analyzed.

Results: A total of 602 HIV patients were genotyped (316 cases and 286 controls). Age and antiretroviral regimen based on protease inhibitors were associated with hypertriglyceridemia (P = 0.0001 and P = 0.0002. respectively). SNP rs964184 GG genotype in APOA5 gene exhibited the highest association with hypertriglyceridemia risk (OR, 3.2, 95% CI, 1.7-5.8, P = 0.0001); followed by SNP rs139961185 in SIK3 gene (OR = 2.3; (95% CI, 1.1-4.8; P = 0.03 for AA vs. AG genotype; and APOC3 rs5128 GG genotype, (OR, 2.2; 95% CI, 1.1-4.9; P = 0.04) under codominant models. These associations were maintained in the adjusted analysis by age and protease inhibitors based antiretroviral regimens.

Conclusions: This study reveals an association between rs964184 in APOA5; rs5128 in APOC3 and rs139961185 in SIK3 and high triglyceride concentrations in Mexican HIV-patients receiving protease inhibitors. These genetic factors may influence the adverse effects related to antiretroviral therapy.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
APOA5, APOC3, CETP, ABCA1和SIK3基因变异对接受抗逆转录病毒治疗的墨西哥hiv患者高甘油三酯血症发展的贡献
目的:探讨APOA5、APOC3、CETP、ATP结合盒转运体A1和SIK3基因单核苷酸多态性(snp)在抗逆转录病毒治疗HIV患者高甘油三酯血症发生中的影响。材料和方法:采用病例对照研究。对接受抗逆转录病毒治疗的墨西哥混血HIV感染高甘油三酯血症(>1.7 mmol/L)患者,提取白血病基因组DNA,采用TaqMan等位基因鉴别技术,实时荧光定量pcr对rs662799、rs964184、rss5128、rs2854116、rs2854117、rs3764261、rs4149310、rs4149267和rs139961185进行基因分型。在正常血脂HIV患者(≤1.7 mmol/L)的对照组中也研究了遗传变异。分析单倍型和基因相互作用。结果:共对602例HIV患者进行基因分型,其中病例316例,对照组286例。年龄和基于蛋白酶抑制剂的抗逆转录病毒治疗方案与高甘油三酯血症相关(P = 0.0001和P = 0.0002)。分别)。APOA5基因SNP rs964184 GG基因型与高甘油三酯血症风险相关性最高(OR, 3.2, 95% CI, 1.7 ~ 5.8, P = 0.0001);其次是SIK3基因rs139961185 SNP (OR = 2.3;(95% ci, 1.1-4.8;AA与AG基因型差异P = 0.03;APOC3 rs5128 GG基因型,(OR, 2.2;95% ci, 1.1-4.9;P = 0.04)。在年龄和基于蛋白酶抑制剂的抗逆转录病毒治疗方案的校正分析中,这些关联得以维持。结论:本研究揭示了rs964184与APOA5;在接受蛋白酶抑制剂的墨西哥hiv患者中,APOC3中的rss5128和SIK3中的rs139961185和高甘油三酯浓度。这些遗传因素可能影响与抗逆转录病毒治疗相关的不良反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Pharmacogenetics and genomics
Pharmacogenetics and genomics 医学-生物工程与应用微生物
CiteScore
3.20
自引率
3.80%
发文量
47
审稿时长
3 months
期刊介绍: ​​​​Pharmacogenetics and Genomics is devoted to the rapid publication of research papers, brief review articles and short communications on genetic determinants in response to drugs and other chemicals in humans and animals. The Journal brings together papers from the entire spectrum of biomedical research and science, including biochemistry, bioinformatics, clinical pharmacology, clinical pharmacy, epidemiology, genetics, genomics, molecular biology, pharmacology, pharmaceutical sciences, and toxicology. Under a single cover, the Journal provides a forum for all aspects of the genetics and genomics of host response to exogenous chemicals: from the gene to the clinic.
期刊最新文献
Polygenic risk score for drug-induced long QT syndrome: independent validation in a real-world patient cohort. The Pharmacogenomics Global Research Network Implementation Working Group: global collaboration to advance pharmacogenetic implementation. Updated analysis of the pharmacogenomics of pediatric bronchodilator response. Association of ADH1B and ALDH2 genotypes with the risk of lung adenocarcinoma. Differential distribution of NAT2 polymorphisms and NAT2 acetylator phenotypes among indigenous populations of the Brazilian Amazon.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1