A case of histological diagnosis of Toxoplasma gondii myositis in a person living with HIV.

Q2 Medicine Infezioni in Medicina Pub Date : 2023-01-01 DOI:10.53854/liim-3103-16

Ilaria De Benedetto, Francesco Biagini, Guido Urbano, Tiziana Enrica Mongini, Ilaria Cassetta, Luca Scaglione, Antonio Curtoni, Guido Calleri, Andrea Calcagno, Francesco Giuseppe De Rosa, Silvia Corcione

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Abstract

We report the case of a 58-year-old male with a recent diagnosis of HIV infection admitted for progressive muscular weakness and psychomotor impairment. Cerebrospinal examination documented a mild hyperproteinorrachia, with normal cells count and reduced glycorrhachia. Brain gadolinium-enhanced MRI showed bilateral T2 and FLAIR hyperintensities in the nucleo-capsular region and irregular contrast-enhancement of the globi pallidi and the right putamen. The histologic analysis of a quadriceps biopsy showed several foci of inflammatory infiltrates with concomitant muscular fiber atrophy and degeneration. Scattered intracytoplasmic inclusions were observed in muscle fibers, representing the main pathological feature. A positive PCR for Toxoplasma gondii and a Toxoplasma gondii specific monoclonal antibody immunohistochemical staining confirmed the diagnosis.

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爱滋病毒感染者刚地弓形虫肌炎组织学诊断1例。

我们报告的情况下，58岁的男性最近诊断为艾滋病毒感染承认进行性肌肉无力和精神运动障碍。脑脊液检查显示轻度高蛋白漏液，细胞计数正常，糖漏液减少。脑钆增强MRI显示双侧核包膜区T2和FLAIR高信号，苍白球和右侧壳核不规则增强。四头肌活检的组织学分析显示了几个炎症浸润灶，并伴有肌肉纤维萎缩和变性。肌纤维内可见分散的胞浆内包涵体，为主要病理特征。弓形虫PCR阳性和弓形虫特异性单克隆抗体免疫组化染色证实了诊断。

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来源期刊

Infezioni in Medicina Medicine-Infectious Diseases

CiteScore

8.40

自引率

0.00%

发文量

期刊介绍： The Journal publishes original papers, in Italian or in English, on topics concerning aetiopathogenesis, prevention, epidemiology, diagnosis, clinical features and therapy of infections, whose acceptance is subject to the referee’s assessment. The Journal is of interest not only to infectious disease specialists, microbiologists and pharmacologists, but also to internal medicine specialists, paediatricians, pneumologists, and to surgeons as well. The Editorial Board includes experts in each of the above mentioned fields.