Taurine in Septic Critically Ill Patients: Plasma versus Blood.

IF 3.1 Q2 PHARMACOLOGY & PHARMACY Advanced pharmaceutical bulletin Pub Date : 2023-01-01 DOI:10.34172/apb.2023.015
Ata Mahmoodpoor, Afsaneh Farjami, Niloufar Farzan, Hamed Hamishehkar, Parina Asgharian, Sarvin Sanaie, Kamran Shadvar, Farnaz Naeimzadeh, Hadi Hamishehkar
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Abstract

Purpose: Sepsis and systemic inflammatory response syndrome (SIRS) encompass various problems throughout the body, and two of its major problems are the creation of oxidative substances in the body and decrease of the body's antioxidant capacity to deal with the stress and organ damage. Optimal enteral nutrition fortified with antioxidant or immunomodulator amino acid is a hot topic concerning sepsis in the critical care setting. Taurine plays a protective role as an antioxidant in cells that is likely to have a protective role in inflammation and cytotoxicity. Methods: In the present study, 20 septic patients and 20 healthy volunteers were enrolled. The blood and plasma taurine levels of the patients on days 1, 3 and 7 were measured. Blood and plasma taurine level and the correlation between them, organ failure, and severity of the disease were assessed. Results: Taurine concentrations in the plasma of the septic patients were significantly lower than control group, and the whole blood concentrations were significantly higher than those of the control group (P<0.001). There was not a significant correlation between the blood and plasma taurine levels in control and septic patients. In addition, there was not any correlation between the severity of the disease, organ failure, mortality, and plasma as well as the blood concentration of taurine. Conclusion: In septic patients, taurine concentration in plasma and blood are low and high, respectively. These concentrations are not linked to each other and not associated with the patients' outcome, and the disease severity, and organ failure.

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牛磺酸在脓毒症危重病人中的作用:血浆vs血液。
目的:脓毒症和全身炎症反应综合征(SIRS)包括全身的各种问题,其中两个主要问题是体内氧化物质的产生和身体抗氧化能力的下降,以应对压力和器官损伤。最佳肠内营养强化抗氧化或免疫调节剂氨基酸是一个热门话题有关败血症在重症监护设置。牛磺酸作为抗氧化剂在细胞中起保护作用,可能在炎症和细胞毒性中起保护作用。方法:选取20例脓毒症患者和20例健康志愿者。测定患者第1、3、7天的血液和血浆牛磺酸水平。评估血液和血浆牛磺酸水平及其与器官衰竭和疾病严重程度的相关性。结果:脓毒症患者血浆中牛磺酸浓度显著低于对照组,全血中牛磺酸浓度显著高于对照组(p结论:脓毒症患者血浆中牛磺酸浓度低,血中牛磺酸浓度高。这些浓度彼此之间没有联系,也与患者的预后、疾病严重程度和器官衰竭无关。
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来源期刊
Advanced pharmaceutical bulletin
Advanced pharmaceutical bulletin PHARMACOLOGY & PHARMACY-
CiteScore
6.80
自引率
2.80%
发文量
51
审稿时长
12 weeks
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