Unlocking the potential of targeting histone-modifying enzymes for treating IBD and CRC.

IF 5.7 2区 医学 Q1 Medicine Clinical Epigenetics Pub Date : 2023-09-11 DOI:10.1186/s13148-023-01562-1
Bing Liang, Yanhong Wang, Jiazhen Xu, Yingchun Shao, Dongming Xing
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Abstract

Dysregulation of histone modifications has been implicated in the pathogenesis of both inflammatory bowel disease (IBD) and colorectal cancer (CRC). These diseases are characterized by chronic inflammation, and alterations in histone modifications have been linked to their development and progression. Furthermore, the gut microbiota plays a crucial role in regulating immune responses and maintaining gut homeostasis, and it has been shown to exert effects on histone modifications and gene expression in host cells. Recent advances in our understanding of the roles of histone-modifying enzymes and their associated chromatin modifications in IBD and CRC have provided new insights into potential therapeutic interventions. In particular, inhibitors of histone-modifying enzymes have been explored in clinical trials as a possible therapeutic approach for these diseases. This review aims to explore these potential therapeutic interventions and analyze previous and ongoing clinical trials that examined the use of histone-modifying enzyme inhibitors for the treatment of IBD and CRC. This paper will contribute to the current body of knowledge by exploring the latest advances in the field and discussing the limitations of existing approaches. By providing a comprehensive analysis of the potential benefits of targeting histone-modifying enzymes for the treatment of IBD and CRC, this review will help to inform future research in this area and highlight the significance of understanding the functions of histone-modifying enzymes and their associated chromatin modifications in gastrointestinal disorders for the development of potential therapeutic interventions.

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释放靶向组蛋白修饰酶治疗IBD和CRC的潜力。
组蛋白修饰的失调与炎症性肠病(IBD)和癌症(CRC)的发病机制有关。这些疾病的特点是慢性炎症,组蛋白修饰的改变与它们的发展和进展有关。此外,肠道微生物群在调节免疫反应和维持肠道稳态方面发挥着至关重要的作用,并已被证明对宿主细胞中的组蛋白修饰和基因表达产生影响。最近,我们对组蛋白修饰酶及其相关染色质修饰在IBD和CRC中的作用的理解取得了进展,为潜在的治疗干预措施提供了新的见解。特别是,组蛋白修饰酶抑制剂已在临床试验中被探索为治疗这些疾病的可能方法。这篇综述旨在探索这些潜在的治疗干预措施,并分析先前和正在进行的临床试验,这些试验检查了组蛋白修饰酶抑制剂用于治疗IBD和CRC。本文将通过探索该领域的最新进展和讨论现有方法的局限性,为当前的知识体系做出贡献。通过对靶向组蛋白修饰酶治疗IBD和CRC的潜在益处进行全面分析,这篇综述将有助于为该领域的未来研究提供信息,并强调了解组蛋白修饰酶及其相关染色质修饰在胃肠道疾病中的作用对开发潜在的治疗干预措施的重要性。
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来源期刊
Clinical Epigenetics
Clinical Epigenetics Biochemistry, Genetics and Molecular Biology-Developmental Biology
CiteScore
8.90
自引率
5.30%
发文量
150
审稿时长
12 weeks
期刊介绍: Clinical Epigenetics, the official journal of the Clinical Epigenetics Society, is an open access, peer-reviewed journal that encompasses all aspects of epigenetic principles and mechanisms in relation to human disease, diagnosis and therapy. Clinical trials and research in disease model organisms are particularly welcome.
期刊最新文献
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