Analysis Of The Association Between Sh2B1 chr16.28884655 And Type 2 Diabetes.

IF 1.2 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Clinical and Investigative Medicine Pub Date : 2022-12-31 DOI:10.25011/cim.v45i4.39273

Jingjin Liu, Renjun Cao, Dewei Li, Fang Miao, Ping An Yang, Hui He, Han Yu, Xiang Zhang, Jie Qin, Yanlan Yang

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Abstract

Purpose: To determine correlation between genetic susceptibility of type 2 diabetes mellitus (T2DM) and Src homology 2 B adapter protein 1 (SH2B1) gene polymorphism in a diabetic population. Methods: A total of 111 T2DM patients (DM group) and 34 healthy controls (NC group) from Shanxi Provincial People's Hospital were included in this study. Exon 9 of the SH2B1 gene was detected using the Sanger sequencing method, and the relationship between SH2B1 gene polymorphism and diabetes was analyzed. Results: Comparison of the data between the two groups showed that the values of TG, the updated HOMA of insulin resistance (HOMA2-IR), weight, body mass index, waist circumference, fasting blood glucose and fasting insulin levels of the DM group were higher than those of the NC group (P < 0.05). The HOMA2 insulin sensitivity (%S) of the DM group was lower than that of the NC group (P < 0.05). Sequencing analysis revealed that the following five single nucleotide polymorphisms in exon 9 of SH2B1 may be related to T2DM: rs181578610, rs550079240, chr16.28884655, chr16.28884659 and chr16.28884831. Among them, chr16.28884655 was found to be significantly related to diabetes; this site, located on the NM_015503 exon, was related to TG, LDL-C and waist circumference.

Conclusion: The SH2B1 gene locus chr16.28884655 was found to be significantly related to genetic susceptibility to T2DM.

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Sh2B1 chr16.28884655与2型糖尿病的相关性分析

目的:探讨糖尿病人群中2型糖尿病(T2DM)遗传易感性与Src同源性2b适配蛋白1 (SH2B1)基因多态性的相关性。方法:选取山西省人民医院T2DM患者111例(DM组)和健康对照34例(NC组)进行研究。采用Sanger测序法检测SH2B1基因外显子9，分析SH2B1基因多态性与糖尿病的关系。结果:两组数据比较，DM组TG、胰岛素抵抗更新HOMA (HOMA2-IR)、体重、体质指数、腰围、空腹血糖、空腹胰岛素水平均高于NC组(P < 0.05)。DM组HOMA2胰岛素敏感性(%S)低于NC组(P < 0.05)。测序分析显示，SH2B1基因第9外显子的5个单核苷酸多态性可能与T2DM相关:rs181578610、rs550079240、chr16.28884655、chr16.28884659和chr16.28884831。其中，发现chr16.28884655与糖尿病显著相关;该位点位于NM_015503外显子，与TG、LDL-C和腰围有关。结论:发现SH2B1基因位点chr16.28884655与T2DM遗传易感性显著相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Investigative Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

12.50%

发文量

审稿时长

>12 weeks

期刊介绍： Clinical and Investigative Medicine (CIM), publishes original work in the field of Clinical Investigation. Original work includes clinical or laboratory investigations and clinical reports. Reviews include information for Continuing Medical Education (CME), narrative review articles, systematic reviews, and meta-analyses.