A systematic review of long non-coding RNAs with a potential role in breast cancer

IF 6.4 2区医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Mutation Research-Reviews in Mutation Research Pub Date : 2021-01-01 DOI:10.1016/j.mrrev.2021.108375

Reza Heidari , Mostafa Akbariqomi , Yazdan Asgari , Diako Ebrahimi , Hamid Alinejad-Rokny

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引用次数: 20

Abstract

The human transcriptome contains many non-coding RNAs (ncRNAs), which play important roles in gene regulation. Long noncoding RNAs (lncRNAs) are an important class of ncRNAs with lengths between 200 and 200,000 bases. Unlike mRNA, lncRNA lacks protein-coding features, specifically, open-reading frames, and start and stop codons. LncRNAs have been reported to play a role in the pathogenesis and progression of many cancers, including breast cancer (BC), acting as tumor suppressors or oncogenes. In this review, we systematically mined the literature to identify 65 BC-related lncRNAs. We then perform an integrative bioinformatics analysis to identify 14 lncRNAs with a potential regulatory role in BC. The biological function of these 14 lncRNAs, their regulatory mechanisms, and roles in the initiation and progression of BC are discussed in this review. Additionally, we elaborate on the current and future applications of lncRNAs as diagnostic and/or therapeutic biomarkers in BC.

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长链非编码rna在乳腺癌中潜在作用的系统综述

人类转录组包含许多非编码rna (ncRNAs)，它们在基因调控中起着重要作用。长链非编码rna (Long noncoding rna, lncrna)是一类重要的非编码rna，其长度在200 - 200,000个碱基之间。与mRNA不同，lncRNA缺乏蛋白质编码特征，特别是开放阅读框架和开始和停止密码子。据报道，LncRNAs在包括乳腺癌(BC)在内的许多癌症的发病和进展中发挥着肿瘤抑制或癌基因的作用。在这篇综述中，我们系统地挖掘了65个bc相关的lncrna。然后，我们进行了综合生物信息学分析，以确定14个在BC中具有潜在调节作用的lncrna。本文就这14种lncrna的生物学功能、调控机制以及在BC发生和发展中的作用进行了综述。此外，我们详细阐述了lncrna作为BC诊断和/或治疗生物标志物的当前和未来应用。

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来源期刊

Mutation Research-Reviews in Mutation Research 生物-毒理学

CiteScore

12.20

自引率

1.90%

发文量

审稿时长

15.7 weeks

期刊介绍： The subject areas of Reviews in Mutation Research encompass the entire spectrum of the science of mutation research and its applications, with particular emphasis on the relationship between mutation and disease. Thus this section will cover advances in human genome research (including evolving technologies for mutation detection and functional genomics) with applications in clinical genetics, gene therapy and health risk assessment for environmental agents of concern.