Antidiabetic effects of Eryngium billardieri hydrosol in the treatment of type 2 diabetic patients: A double-blind randomized clinical trial.

IF 1.9 Q3 CHEMISTRY, MEDICINAL Avicenna Journal of Phytomedicine Pub Date : 2023-01-01 DOI:10.22038/AJP.2022.21175
Zahra Hamami Chamgordani, Mohammad Mazaheri, Bijan Iraj, Hojjat Baghshahi, Fakhri Sabouhi
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引用次数: 1

Abstract

Objective: Medicinal plants with fewer side effects and low cost than synthetic medicines are increasingly advised to treat diseases. The present study aimed to identify Eryngium billardieri compounds and evaluate the plant's effects on hyperglycemic and hyperlipidemia indices, and liver, and kidney function.

Materials and methods: Following identification of Eryngium billardieri using GC/MS method, 72 participants were randomly divided into two groups (n=36 per group), receiving oral hypoglycemic medication (metformin) with or without 50 ml hydrosol twice a day for three months as intervention and placebo control, respectively. Body mass index (BMI), systolic and diastolic blood pressure, fasting blood sugar (FBS), glycosylated hemoglobin (HbA1c), total cholesterol, triglyceride, HDL-C, and LDL-C levels were measured at the beginning and end of the experiment. Also, aspartate transaminase, alanine transaminase, blood urea nitrogen, and creatinine levels were measured to assess adverse effects on liver and kidney functions.

Results: The main components were terpenes with 46.69% of the total ingredients of E. billardieri essential oil. Other prominent compounds identified included octanoic acid (12.14 %) and isoxazole (6.72 %). Intergroup changes in blood parameters showed that E. billardieri hydrosol for three months could significantly reduce HbA1C and blood cholesterol levels but did not affect other measured parameters. Also, there were no adverse effects on kidney or liver function.

Conclusion: The present findings showed that the consumption of 50 ml of E. billardieri hydrosol as a complementary treatment in diabetic patients reduced HbA1C and cholesterol levels without adverse effects on the liver or kidneys functions.

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双盲随机临床试验:比拉氏杏鲍水溶胶治疗2型糖尿病患者的抗糖尿病作用。
目的:与合成药物相比,副作用较少、成本较低的药用植物越来越多地被建议用于治疗疾病。本研究旨在鉴定比氏杏鲍的化合物,并评估该植物对高血糖和高脂血症指数以及肝肾功能的影响。材料和方法:使用GC/MS法鉴定比拉氏杏鲍后,72名参与者被随机分为两组(每组n=36),分别接受口服降糖药物(二甲双胍),每天两次,含或不含50ml水溶胶,为期三个月,作为干预和安慰剂对照。在实验开始和结束时测量身体质量指数(BMI)、收缩压和舒张压、空腹血糖(FBS)、糖化血红蛋白(HbA1c)、总胆固醇、甘油三酯、HDL-C和LDL-C水平。此外,还测量了天冬氨酸转氨酶、丙氨酸转氨酶、血尿素氮和肌酐水平,以评估对肝肾功能的不良影响。结果:主要成分为萜类化合物,占比拉地埃挥发油总成分的46.69%。已鉴定的其他突出化合物包括辛酸(12.14%)和异恶唑(6.72%)。血液参数的组间变化表明,E.billardieri水溶胶持续三个月可显著降低HbA1C和血液胆固醇水平,但不影响其他测量参数。此外,没有对肾脏或肝脏功能产生不良影响。结论:目前的研究结果表明,在糖尿病患者中,食用50毫升比拉狄里水溶胶作为补充治疗,可以降低HbA1C和胆固醇水平,而不会对肝脏或肾脏功能产生不利影响。
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来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
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