Update on the treatment of multisystem inflammatory syndrome in children associated with COVID-19.

IF 2.1 4区 医学 Q3 VIROLOGY Future Virology Pub Date : 2022-12-01 DOI:10.2217/fvl-2022-0048
Fangyuan Long, Shiheng Zhu, Zeguang Wang, Shungeng Zhang, Jinlong He, Xinbin Ge, Jun Ning
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引用次数: 3

Abstract

In late 2019, SARS-CoV-2 was detected in China and spread worldwide. In rare cases, children who were infected with COVID-19 may develop multisystem inflammatory syndrome (MIS-C), which could have higher mortality than COVID-19 itself. Therefore, diagnosis and management are critical for treatment. Specifically, most of the initial treatment options of MIS-C choose intravenous immunoglobulin (IVIG) and steroids as the first-line treatment for patients. Moreover, antagonists of some cytokines are used as potential future therapeutics. Of note, therapeutic plasmapheresis can be used as a treatment for refractory severe MIS-C. We believe that each patient, especially those with comorbid conditions, should have individualized treatment based on both multidisciplinary consensus approach and expert opinion.

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与COVID-19相关的儿童多系统炎症综合征治疗进展
2019年底,SARS-CoV-2在中国被发现并传播到世界各地。在极少数情况下,感染COVID-19的儿童可能会出现多系统炎症综合征(MIS-C),其死亡率可能高于COVID-19本身。因此,诊断和管理对治疗至关重要。具体而言,大多数MIS-C的初始治疗方案选择静脉注射免疫球蛋白(IVIG)和类固醇作为患者的一线治疗。此外,一些细胞因子的拮抗剂被用作潜在的未来治疗药物。值得注意的是,治疗性血浆置换可用于治疗难治性重度misc。我们认为,每个患者,特别是那些有合并症的患者,应该在多学科共识方法和专家意见的基础上进行个体化治疗。
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来源期刊
Future Virology
Future Virology 医学-病毒学
CiteScore
4.00
自引率
3.20%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Future Virology is a peer-reviewed journal that delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this ever-expanding area of research. It is an interdisciplinary forum for all scientists working in the field today.
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