Six Decades of History of Hypertension Research at the University of Toledo: Highlighting Pioneering Contributions in Biochemistry, Genetics, and Host-Microbiota Interactions.

IF 3.9 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Current Hypertension Reports Pub Date : 2022-12-01 Epub Date: 2022-10-27 DOI:10.1007/s11906-022-01226-0
Veda Gokula, David Terrero, Bina Joe
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Abstract

Purpose of review: The study aims to capture the history and lineage of hypertension researchers from the University of Toledo in Ohio and showcase their collective scientific contributions dating from their initial discoveries of the physiology of adrenal and renal systems and genetics regulating blood pressure (BP) to its more contemporary contributions including microbiota and metabolomic links to BP regulation.

Recent findings: The University of Toledo College of Medicine and Life Sciences (UTCOMLS), previously known as the Medical College of Ohio, has contributed significantly to our understanding of the etiology of hypertension. Two of the scientists, Patrick Mulrow and John Rapp from UTCOMLS, have been recognized with the highest honor, the Excellence in Hypertension award from the American Heart Association for their pioneering work on the physiology and genetics of hypertension, respectively. More recently, Bina Joe has continued their legacy in the basic sciences by uncovering previously unknown novel links between microbiota and metabolites to the etiology of hypertension, work that has been recognized by the American Heart Association with multiple awards. On the clinical research front, Christopher Cooper and colleagues lead the CORAL trials and contributed importantly to the investigations on renal artery stenosis treatment paradigms. Hypertension research at this institution has not only provided these pioneering insights, but also grown careers of scientists as leaders in academia as University Presidents and Deans of Medical Schools. Through the last decade, the university has expanded its commitment to Hypertension research as evident through the development of the Center for Hypertension and Precision Medicine led by Bina Joe as its founding Director. Hypertension being the top risk factor for cardiovascular diseases, which is the leading cause of human mortality, is an important area of research in multiple international universities. The UTCOMLS is one such university which, for the last 6 decades, has made significant contributions to our current understanding of hypertension. This review is a synthesis of this rich history. Additionally, it also serves as a collection of audio archives by more recent faculty who are also prominent leaders in the field of hypertension research, including John Rapp, Bina Joe, and Christopher Cooper, which are cataloged at Interviews .

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托莱多大学高血压研究六十年的历史:突出在生物化学、遗传学和宿主与微生物群相互作用方面的开创性贡献。
回顾的目的:该研究旨在记录俄亥俄州托莱多大学高血压研究人员的历史和脉络,展示他们从最初发现肾上腺和肾脏系统的生理学以及调节血压(BP)的遗传学,到包括微生物群和代谢组与血压调节的联系在内的当代贡献:托莱多大学医学与生命科学学院(UTCOMLS)(前身为俄亥俄医学院)为我们了解高血压的病因做出了重大贡献。UTCOMLS的两位科学家帕特里克-穆罗(Patrick Mulrow)和约翰-拉普(John Rapp)分别因其在高血压生理学和遗传学方面的开创性工作获得了美国心脏协会颁发的最高荣誉--高血压卓越奖。最近,比娜-乔继续他们在基础科学领域的工作,发现了微生物群和代谢物与高血压病因之间之前未知的新联系,这项工作获得了美国心脏协会颁发的多个奖项。在临床研究方面,克里斯托弗-库珀及其同事领导了 CORAL 试验,为肾动脉狭窄治疗范例的研究做出了重要贡献。该机构的高血压研究不仅提供了这些开创性的见解,还使科学家的职业生涯不断发展,成为大学校长和医学院院长等学术界领袖。在过去的十年中,该大学扩大了对高血压研究的投入,由 Bina Joe 担任创始主任的高血压和精准医学中心的发展就证明了这一点。高血压是心血管疾病的首要风险因素,也是人类死亡的主要原因,是多所国际大学的重要研究领域。UTCOMLS就是这样一所大学,在过去的60年里,它为我们目前对高血压的了解做出了重大贡献。本综述是对这一丰富历史的总结。此外,它还收集了约翰-拉普(John Rapp)、比娜-乔(Bina Joe)和克里斯托弗-库珀(Christopher Cooper)等在高血压研究领域有突出贡献的新近教师的音频档案,这些档案编目于 Interviews .
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来源期刊
Current Hypertension Reports
Current Hypertension Reports 医学-外周血管病
CiteScore
10.50
自引率
0.00%
发文量
65
审稿时长
6-12 weeks
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of hypertension. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antihypertensive therapies, associated metabolic disorders, and therapeutic trials. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
期刊最新文献
Is There a Role for SGLT2 Inhibitors in Patients with End-Stage Kidney Disease? Advances on the Experimental Research in Resistant Hypertension. Importance of the (Pro)renin Receptor in Activating the Renin-Angiotensin System During Normotensive and Preeclamptic Pregnancies. Hypertension and Cardiovascular Outcomes in Inflammatory and Autoimmune Diseases: A Systematic Review and Meta-analysis. Pediatric Blood Pressure and Cardiovascular Health in Adulthood.
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