Arterial Stiffness and the Canonical WNT/β-catenin Pathway.

IF 3.9 2区医学 Q1 PERIPHERAL VASCULAR DISEASE Current Hypertension Reports Pub Date : 2022-11-01 DOI:10.1007/s11906-022-01211-7

Alexandre Vallée

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引用次数: 2

Abstract

Purpose of review: Arterial stiffness (AS) was mainly associated with cardiovascular morbidity and mortality in a hypertensive patient. Some risk factors contribute to the development of AS, such as aging, high blood pressure, vascular calcification, inflammation, and diabetes mellitus. The WNT/β-catenin pathway is implicated in numerous signaling and regulating pathways, including embryogenesis, cell proliferation, migration and polarity, apoptosis, and organogenesis. The activation of the WNT/β-catenin pathway is associated with the development of these risk factors.

Recent findings: Aortic pulse wave velocity (PWV) is measured to determine AS, and in peripheral artery disease patients, PWV is higher than controls. An augmentation in PWV by 1 m/s has been shown to increase the risk of cardiovascular events by 14%. AS measured by PWV is characterized by the deregulation of the WNT/β-catenin pathway by the inactivation of its two inhibitors, i.e., DKK1 and sclerostin. Thus, this review focuses on the role of the WNT/β-catenin pathway which contributes to the development of arterial stiffness.

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动脉僵硬和典型WNT/β-catenin通路。

回顾目的:动脉僵硬(AS)主要与高血压患者心血管疾病发病率和死亡率相关。一些危险因素有助于AS的发展，如衰老，高血压，血管钙化，炎症和糖尿病。WNT/β-catenin通路涉及许多信号传导和调节通路，包括胚胎发生、细胞增殖、迁移和极性、凋亡和器官发生。WNT/β-catenin通路的激活与这些危险因素的发展有关。最近的发现:主动脉脉冲波速度(PWV)被测量来判断AS，在外周动脉疾病患者中，PWV高于对照组。PWV每增加1 m/s，心血管事件的风险增加14%。通过PWV测量的AS的特征是WNT/β-catenin通路通过其两个抑制剂(即DKK1和sclerostin)的失活而解除管制。因此，本文主要关注WNT/β-catenin通路在动脉硬化发展中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Hypertension Reports 医学-外周血管病

CiteScore

10.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of hypertension. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antihypertensive therapies, associated metabolic disorders, and therapeutic trials. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.