Irisin expression and FNDC5 (rs3480) gene polymorphism in type 2 diabetic patients with and without CAD.

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM Archives of Physiology and Biochemistry Pub Date : 2024-10-01 Epub Date: 2023-02-02 DOI:10.1080/13813455.2023.2173785

Amera Morad Foad, Alshimaa Hafez, Wael Youssef, Ahmed Elsharawy Ahmed, Ali Mohamad Altaher

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Abstract

Background: Irisin was found to correlate with coronary artery disease (CAD) in diabetic patients. This study investigated the association of irisin and FNDC5 (SNP rs3480) with the presence and severity of CAD in T2DM.

Methods: This cross-sectional study included 100 patients with T2DM divided into two groups, DM group (n = 50), including patients without CAD and CAD group (n = 50), including those confirmed to have CAD by coronary angiography. Irisin was measured. SNP rs3480 genotyping of FNDC5 was done.

Results: Irisin levels were significantly lower in the CAD group (p < 0.001). The CAD group had significantly higher HbA1c and lower HDL (p < 0.001). Patients with controlled DM had significantly higher irisin levels (p < 0.001). single nucleotide polymorphism (SNP) rs3480 was not associated with irisin levels, and the FNDC5 rs3480 AA reference allele was significantly associated with significant CAD.

Conclusion: Irisin appears to be protective against developing CAD in diabetic patients. Irisin level was an independent predictor of significant CAD in diabetic patients combined with the FNDC5 rs3480 genotype.

Clinical trial registration number: NCT04957823.

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患有和未患有 CAD 的 2 型糖尿病患者的鸢尾素表达和 FNDC5 (rs3480) 基因多态性。

背景：研究发现鸢尾素与糖尿病患者的冠状动脉疾病（CAD）相关。本研究探讨了鸢尾素和 FNDC5（SNP rs3480）与 T2DM 患者是否患有 CAD 及其严重程度的关系：这项横断面研究纳入了 100 名 T2DM 患者，分为两组，DM 组（n = 50），包括无 CAD 的患者；CAD 组（n = 50），包括经冠状动脉造影证实患有 CAD 的患者。测量鸢尾素。对 FNDC5 的 SNP rs3480 进行了基因分型：结果：CAD 组的鸢尾素水平明显较低（p p p FNDC5 rs3480 AA 参考等位基因与明显的 CAD 显著相关：结论：鸢尾素对糖尿病患者的CAD具有保护作用。结论：鸢尾素对糖尿病患者罹患CAD具有保护作用，鸢尾素水平是糖尿病患者合并FNDC5 rs3480基因型后出现明显CAD的独立预测因子：临床试验注册号：NCT04957823。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.