Association of volatile organic compounds exposure with the risk of depression in U.S. adults: a cross‑sectional study from NHANES 2013-2016.

IF 2.6 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH International Archives of Occupational and Environmental Health Pub Date : 2023-10-01 Epub Date: 2023-06-27 DOI:10.1007/s00420-023-01993-6

Yue Zhu, Yinghui Ju, Menglin Wang, Yuying Yang, Rui Wu

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Abstract

Background: Volatile organic compounds (VOCs) are a broad class of chemicals, and previous studies showed that VOCs could increase the risk of central nervous system disorders. However, few studies have comprehensively explored their association with depression among general adults.

Objective: We aimed to explore the association between blood VOCs and depression risk based on a large cross-sectional study of the National Health and Nutrition Examination Survey (NHANES).

Methods: We analyzed data from 3449 American adults in the NHANES 2013-2016. Survey-weighted logistic regression model was used to explore the association of ten blood VOCs with depression. Subsequently, the relative importance of the selected VOCs was determined using the XGBoost model. The weighted quantile sum (WQS) regression model was used to explore the overall association of 10 blood VOCs with depression. Subgroup analyses were performed to identify high-risk populations. Finally, restricted cubic spline (RCS) analysis was utilized to explore the dose-response relationship between blood VOCs and the risk of depression.

Results: XGBoost Algorithm model identified blood 2,5-dimethylfuran was the most critical variable in depression. The logistic regression model showed that blood benzene, blood 2,5-dimethylfuran, and blood furan showed a positive correlation with depression. In subgroup analysis, we found that the effects of the above VOCs on depression existed among the female, young middle-aged, and overweight-obese population. Mixture VOCs exposure was positively associated with depression risk (OR = 2.089, 95% CI: 1.299-3.361), and 2,5-dimethylfuran had the largest weights in WQS regression. RCS displayed that blood benzene, blood 2,5-dimethylfuran, and blood furan were positively associated with depression.

Conclusion: The results of this study indicated that VOCs exposure was associated with an increased prevalence of depression in U.S. adults. Women, young and middle-aged, and overweight-obese populations are more vulnerable to VOCs.

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挥发性有机化合物暴露与美国成年人抑郁症风险的关系：2013年至2016年NHANES的一项横断面研究。

背景：挥发性有机化合物（VOCs）是一类广泛的化学物质，先前的研究表明，VOCs会增加中枢神经系统疾病的风险。然而，很少有研究全面探讨它们与普通成年人抑郁症的关系。目的：基于美国国家健康与营养调查（NHANES）的一项大型横断面研究，我们旨在探讨血液挥发性有机物与抑郁症风险之间的关系。方法：我们分析了2013年至2016年NHANES中3449名美国成年人的数据。采用调查加权逻辑回归模型探讨10种血液挥发性有机物与抑郁症的关系。随后，使用XGBoost模型确定所选VOC的相对重要性。使用加权分位数和（WQS）回归模型来探索10种血液VOC与抑郁症的总体关联。进行亚组分析以确定高危人群。最后，利用限制性三次样条（RCS）分析来探讨血液VOCs与抑郁症风险之间的剂量-反应关系。结果：XGBoost算法模型确定血液中2,5-二甲基呋喃是抑郁症最关键的变量。logistic回归模型显示，血苯、血2,5-二甲基呋喃和血呋喃与抑郁症呈正相关。在亚组分析中，我们发现上述挥发性有机物对抑郁症的影响存在于女性、青壮年和超重肥胖人群中。混合挥发性有机物暴露与抑郁风险呈正相关（OR = 2.089，95%CI:1.299-3.361），并且2,5-二甲基呋喃在WQS回归中具有最大的权重。RCS显示血苯、血2,5-二甲基呋喃和血呋喃与抑郁症呈正相关。结论：本研究结果表明，挥发性有机物暴露与美国成年人抑郁症患病率增加有关。女性、中青年和超重肥胖人群更容易受到挥发性有机物的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

5.60

自引率

6.70%

发文量

127

审稿时长

3 months

期刊介绍： International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.