Alcohol consumption affects the late endocrine consequences of mild traumatic brain injury.

IF 0.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM Neuro endocrinology letters Pub Date : 2022-11-30

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Abstract

Background: Currently there are no widely applied methods which could identify, at the time of head trauma, those mild traumatic brain injury (mTBI) patients who later develop pituitary dysfunction. The effect of alcohol consumption on post-TBI endocrine dysfunction is unclear.

Methods: Five hundred and eight TBI patients, 406 of them with mTBI, were studied. Sixty-one patients (46 males, 15 females) were available for follow-up. Admission serum samples were evaluated for S100B protein and markers of alcohol consumption: ethanol level for day-of-injury intake and carbohydrate deficient transferrin (CDT) level for regular alcohol consumption. Regular alcohol consumption was defined as CDT > 1.5%, including both social and heavy drinkers. Admission and one-year follow-up samples were evaluated for pituitary dysfunction.

Results: Newly developed pituitary hormone deﬁciency was found in 16% of mTBI patients. When cohorts developing and not developing late pituitary dysfunction were compared, 30% and 69% of patients were regular alcohol consumers, respectively (p = 0.02). Neither S100B level nor day-of-injury alcohol consumption was predictive of late pituitary dysfunction.

Conclusion: The findings of this preliminary study suggest that regular alcohol consumption may protect against the late endocrine consequences of mTBI. Alcohol intake during the weeks preceding mTBI may identify patients at higher risk for late pituitary dysfunction.

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饮酒影响轻度创伤性脑损伤的晚期内分泌后果。

背景:目前还没有一种广泛应用的方法能够在颅脑外伤时识别轻度创伤性脑损伤(mTBI)患者并发垂体功能障碍。饮酒对脑外伤后内分泌功能障碍的影响尚不清楚。方法:对580例TBI患者进行分析，其中合并mTBI患者406例。61例患者(男46例，女15例)接受随访。入院时评估血清样本的S100B蛋白和酒精消耗标志物:损伤日摄入的乙醇水平和定期饮酒的碳水化合物缺乏性转铁蛋白(CDT)水平。经常饮酒定义为CDT > 1.5%，包括社交和重度饮酒者。入院和一年随访样本评估垂体功能障碍。结果:16%的mTBI患者出现新发垂体激素缺乏。当发生和未发生晚期垂体功能障碍的队列进行比较时，分别有30%和69%的患者经常饮酒(p = 0.02)。S100B水平和受伤当天的酒精摄入量都不能预测晚期垂体功能障碍。结论:这项初步研究的结果表明，定期饮酒可以预防mTBI的晚期内分泌后果。mTBI前几周的酒精摄入可以确定晚期垂体功能障碍风险较高的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuro endocrinology letters 医学-内分泌学与代谢

CiteScore

1.00

自引率

14.30%

发文量

审稿时长

6 months

期刊介绍： Neuroendocrinology Letters is an international, peer-reviewed interdisciplinary journal covering the fields of Neuroendocrinology, Neuroscience, Neurophysiology, Neuropsychopharmacology, Psychoneuroimmunology, Reproductive Medicine, Chronobiology, Human Ethology and related fields for RAPID publication of Original Papers, Review Articles, State-of-the-art, Clinical Reports and other contributions from all the fields covered by Neuroendocrinology Letters. Papers from both basic research (methodology, molecular and cellular biology, anatomy, histology, biology, embryology, teratology, normal and pathological physiology, biophysics, pharmacology, pathology and experimental pathology, biochemistry, neurochemistry, enzymology, chronobiology, receptor studies, endocrinology, immunology and neuroimmunology, animal physiology, animal breeding and ethology, human ethology, psychology and others) and from clinical research (neurology, psychiatry and child psychiatry, obstetrics and gynecology, pediatrics, endocrinology, immunology, cardiovascular studies, internal medicine, oncology and others) will be considered. The Journal publishes Original papers and Review Articles. Brief reports, Special Communications, proved they are based on adequate experimental evidence, Clinical Studies, Case Reports, Commentaries, Discussions, Letters to the Editor (correspondence column), Book Reviews, Congress Reports and other categories of articles (philosophy, art, social issues, medical and health policies, biomedical history, etc.) will be taken under consideration.