Insights into the advances in therapeutic drugs for neuroinflammation-related diseases.

IF 1.7 4区医学 Q4 NEUROSCIENCES International Journal of Neuroscience Pub Date : 2024-11-01 Epub Date: 2023-09-21 DOI:10.1080/00207454.2023.2260088

Bozhi Luo

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Abstract

Studies have shown that neurodegenerative diseases such as AD and PD are related to neuroinflammation. Neuroinflammation is a common inflammatory condition that can lead to a variety of dysfunction in the body. At present, it is no medications specifically approved to prevent or cure neuroinflammation, so even though many drugs can temporarily control the neurological symptoms of neuroinflammation, but no one can reverse the progress of neuroinflammation, let al.one completely cure neuroinflammation. Therefore, it is urgent to develop new drug development for neuroinflammation treatment. In this review, we highlight the therapeutic advancement in the field of neurodegenerative disorders, by focusing on the impact of neuroinflammation treatment has on these conditions, and the effective drugs for the treatment of neuroinflammation and neurodegenerative diseases and their latest research progress are reviewed according to the related signaling pathway, as well as the prospect of their clinical application is also discussed. The purpose of this review is to enable specialists to better understand the mechanisms underlying neuroinflammation and anti-inflammatory drugs, promote the development of therapeutic drugs for neuroinflammation and neurodegenerative diseases, and further provide therapeutic references for clinical neurologists.

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对神经炎症相关疾病治疗药物进展的见解。

研究表明，AD和PD等神经退行性疾病与神经炎症有关。神经炎症是一种常见的炎症性疾病，可导致身体的各种功能障碍。目前，还没有专门批准的药物来预防或治疗神经炎症，因此，尽管许多药物可以暂时控制神经炎症的神经症状，但没有人能够逆转神经炎症的进展，更不用说完全治愈神经炎症了。因此，开发治疗神经炎症的新药迫在眉睫。在这篇综述中，我们通过关注神经炎症治疗对这些疾病的影响，强调了神经退行性疾病领域的治疗进展，并根据相关信号通路综述了治疗神经炎症和神经退行性病变的有效药物及其最新研究进展，并对其临床应用前景进行了展望。这篇综述的目的是让专家更好地了解神经炎症和抗炎药的潜在机制，促进神经炎症和神经退行性疾病治疗药物的开发，并进一步为临床神经学家提供治疗参考。

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来源期刊

International Journal of Neuroscience 医学-神经科学

CiteScore

5.10

自引率

0.00%

发文量

132

审稿时长

2 months

期刊介绍： The International Journal of Neuroscience publishes original research articles, reviews, brief scientific reports, case studies, letters to the editor and book reviews concerned with problems of the nervous system and related clinical studies, epidemiology, neuropathology, medical and surgical treatment options and outcomes, neuropsychology and other topics related to the research and care of persons with neurologic disorders. The focus of the journal is clinical and transitional research. Topics covered include but are not limited to: ALS, ataxia, autism, brain tumors, child neurology, demyelinating diseases, epilepsy, genetics, headache, lysosomal storage disease, mitochondrial dysfunction, movement disorders, multiple sclerosis, myopathy, neurodegenerative diseases, neuromuscular disorders, neuropharmacology, neuropsychiatry, neuropsychology, pain, sleep disorders, stroke, and other areas related to the neurosciences.