Long COVID: what is known and what gaps need to be addressed.

IF 6.7 2区医学 Q1 Medicine British medical bulletin Pub Date : 2023-09-12 DOI:10.1093/bmb/ldad016

Benjamin Krishna, Mark Wills, Nyaradzai Sithole

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Abstract

Introduction: Long COVID is a chronic condition that follows after acute COVID-19 and is characterized by a wide range of persistent, cyclic symptoms.

Sources of data: PubMed search for publications featuring 'Long COVID' or 'post-acute sequelae of COVID-19'.

Areas of agreement: Long COVID occurs frequently post-acute COVID-19, with a majority of people experiencing at least one symptom (such as cough, fatigue, myalgia, anosmia and dyspnoea) 4 weeks after infection.

Areas of controversy: The specific symptoms and the minimum duration of symptoms required to be defined as Long COVID.

Growing points: There is a consistent reduction in Long COVID incidence amongst vaccinated individuals, although the extent of this effect remains unclear.

Areas timely for developing research: There is an urgent need to understand the causes of Long COVID, especially extreme fatigue more than 6 months after infection. We must understand who is at risk and whether reinfections similarly risk Long COVID.

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长期新冠肺炎：已知情况和需要解决的差距。

简介：长期新冠肺炎是急性新冠肺炎后的一种慢性疾病，其特征是广泛的持续性周期性症状。数据来源：PubMed搜索以“长期新冠肺炎”或“新冠肺炎急性后后遗症”为主题的出版物。一致的领域：长期新冠病毒在急性新冠肺炎后频繁发生，大多数人在感染后4周至少出现一种症状（如咳嗽、疲劳、肌痛、嗅觉缺失和呼吸困难）。争议领域：需要定义为长期新冠肺炎的具体症状和症状的最短持续时间。增长点：接种疫苗的个体中长期新冠病毒的发病率持续下降，尽管这种影响的程度尚不清楚。及时开展研究的领域：迫切需要了解长期新冠肺炎的原因，尤其是感染后6个月以上的极度疲劳。我们必须了解谁有风险，以及再次感染是否有类似的长期新冠肺炎风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British medical bulletin 医学-医学：内科

CiteScore

13.10

自引率

1.50%

发文量

审稿时长

>12 weeks

期刊介绍： British Medical Bulletin is a multidisciplinary publication, which comprises high quality reviews aimed at generalist physicians, junior doctors, and medical students in both developed and developing countries. Its key aims are to provide interpretations of growing points in medicine by trusted experts in the field, and to assist practitioners in incorporating not just evidence but new conceptual ways of thinking into their practice.