Extensive Multifocal Emphysematous Osteomyelitis of Spine: A Rare Case and a Review of Literature.

Q3 Pharmacology, Toxicology and Pharmaceutics Infectious disorders drug targets Pub Date : 2023-01-01 DOI:10.2174/1871526522666220614163310

Bhawna Sharma, Vikas Lakhanpal, Abeer Goyal, Ritu Shree, Shashank Raj, Priya Sreenivasan, Manisha Biswal, Pallab Ray, Archana Angrup

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引用次数: 2

Abstract

Background: Emphysematous osteomyelitis (EO) is an extremely rare form of osteomyelitis which is complicated mainly by infection with gas-forming organisms. The common causative agents of this disease are mainly members of Enterobacteriaceae family, the most common are Escherichia coli and Klebsiella pneumoniae along with anaerobes. A total of 48 cases of EO have been reported in the literature till now globally and none have documented the isolation of Corynebacterium amycolatum.

Case presentation: We report a rare case of emphysematous osteomyelitis of the spine and pelvis due to Escherichia coli along with the isolation of Corynebacterium amycolatum from the same pus samples on two consecutive occasions in a 50-year-old female with uncontrolled diabetes mellitus, who was successively treated with antibiotics and drainage of pus. We also did a brief review of the literature of all cases reported till now.

Conclusion: The role of Corynebacterium amycolatum in the etiology of emphysematous osteomyelitis needs to be evaluated further in future studies as we cannot completely ignore its isolation in two consecutive samples as a mere contaminant.

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脊柱广泛多灶性肺气肿性骨髓炎:一例罕见病例及文献复习。

背景:肺气肿性骨髓炎(EO)是一种极为罕见的骨髓炎，主要并发有气体形成的微生物感染。本病的常见病原体主要是肠杆菌科的成员，最常见的是大肠杆菌和肺炎克雷伯菌以及厌氧菌。迄今为止，在全球范围内共报道了48例EO病例，尚未报道分离出淀粉状棒状杆菌。病例介绍:我们报告一例罕见的脊柱和骨盆肺气肿性骨髓炎，由大肠杆菌引起，并连续两次从相同的脓液样本中分离出amycolatum棒状杆菌，患者是一名50岁的女性，患有未控制的糖尿病，她先后接受了抗生素治疗和脓液引流。我们也对迄今为止报道的所有病例的文献做了简要的回顾。结论:淀粉状棒状杆菌在肺气肿性骨髓炎的病因学中的作用有待于在今后的研究中进一步评估，因为我们不能完全忽视它在连续两个样本中作为单纯污染物的分离。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infectious disorders drug targets Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

3.10

自引率

0.00%

发文量

123

期刊介绍： Infectious Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in infectious disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in infectious disorders. As the discovery, identification, characterization and validation of novel human drug targets for anti-infective drug discovery continues to grow, this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.