Update on the role of extracellular vesicles in rheumatoid arthritis.

IF 4.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Expert Reviews in Molecular Medicine Pub Date : 2022-03-17 DOI:10.1017/erm.2021.33
Hai-Bing Miao, Fang Wang, Shu Lin, Zhen Chen
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引用次数: 13

Abstract

Rheumatoid arthritis (RA) is a heterogeneous autoimmune disorder that leads to severe joint deformities, negatively affecting the patient's quality of life. Extracellular vesicles (EVs), which include exosomes and ectosomes, act as intercellular communication mediators in several physiological and pathological processes in various diseases including RA. In contrast, EVs secreted by mesenchymal stem cells perform an immunomodulatory function and stimulate cartilage repair, showing promising therapeutic results in animal models of RA. EVs from other sources, including dendritic cells, neutrophils and myeloid-derived suppressor cells, also influence the biological function of immune and joint cells. This review describes the role of EVs in the pathogenesis of RA and presents evidence supporting future studies on the therapeutic potential of EVs from different sources. This information will contribute to a better understanding of RA development, as well as a starting point for exploring cell-free-based therapies for RA.

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细胞外囊泡在类风湿关节炎中的作用的最新进展。
类风湿性关节炎(RA)是一种异质性自身免疫性疾病,可导致严重的关节畸形,对患者的生活质量产生负面影响。细胞外囊泡(EVs)包括外泌体和外泌体,在包括RA在内的多种疾病的一些生理和病理过程中作为细胞间通讯介质。相反,间充质干细胞分泌的ev具有免疫调节功能,刺激软骨修复,在RA动物模型中显示出良好的治疗效果。其他来源的EVs,包括树突状细胞、中性粒细胞和髓源性抑制细胞,也会影响免疫细胞和关节细胞的生物学功能。本文综述了ev在RA发病机制中的作用,并提供了支持未来研究不同来源ev的治疗潜力的证据。这一信息将有助于更好地了解类风湿性关节炎的发展,以及探索无细胞治疗类风湿性关节炎的起点。
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来源期刊
Expert Reviews in Molecular Medicine
Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
7.40
自引率
1.60%
发文量
45
期刊介绍: Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.
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