Recent Treatment Strategies in Alzheimer's Disease and Chronic Traumatic Encephalopathy.

Biomedical research and clinical reviews Pub Date : 2022-01-01 Epub Date: 2022-09-08 DOI:10.31579/2692-9406/128
Yusuf Mehkri, Brandon McDonald, Sai Sriram, Ramya Reddy, Savannah Kounelis-Wuillaume, Jeffrey Alexander Roberts, Brandon Lucke-Wold
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Abstract

Neurotrauma has been well linked to the progression of neurodegenerative disease. Much work has been done characterizing chronic traumatic encephalopathy, but less has been done regarding the contribution to Alzheimer's Disease. This review focuses on AD and its association with neurotrauma. Emerging clinical trials are discussed as well as novel mechanisms. We then address how some of these mechanisms are shared with CTE and emerging pre-clinical studies. This paper is a user-friendly resource that summarizes the emerging findings and proposes further investigation into key areas of interest. It is intended to serve as a catalyst for both research teams and clinicians in the quest to improve effective treatment and diagnostic options.

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阿尔茨海默病和慢性创伤性脑病的最新治疗策略。
神经创伤与神经退行性疾病的进展密切相关。关于慢性创伤性脑病的特征研究已做了大量工作,但关于其对阿尔茨海默病的影响研究较少。本综述将重点关注阿尔茨海默病及其与神经创伤的关系。我们讨论了新的临床试验和新的机制。然后,我们将讨论其中一些机制如何与 CTE 和新出现的临床前研究共享。本文是一份用户友好型资料,总结了新出现的研究结果,并建议对主要关注领域进行进一步研究。本文旨在为研究团队和临床医生提供催化剂,帮助他们改进有效的治疗和诊断方案。
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