[Influence factors of lead in whole blood in the German External Quality Assessment Scheme by ICP-MS].

Miao Zhang, Lei Zheng, Qi Sun, Xiao Lin, Liang Ding
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Abstract

Objective: To investigate the influence factors of lead in whole blood in the German External Quality Assessment Scheme(G-EQUAS) biological materials by inductively coupled plasma mass spectrometry(ICP-MS) from 2018 to 2020.

Methods: ICP-MS was used to determine lead in whole blood of G-EQUAS by optimizing the reaction gas mode, sample dilution ratio, internal standard element, isotope and so on, analyzed the result.

Results: This study indicated that selection of internal standard elements, isotopes, matrix effect and physical effect may affect the accuracy of ICP-MS determination of lead in biological samples.

Conclusion: Avoided the factors that may affect the result when determining lead in whole blood by ICP-MS.

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[德国ICP-MS外部质量评价方案中全血铅的影响因素]。
目的:采用电感耦合等离子体质谱法(ICP-MS)研究2018 - 2020年德国外部质量评价体系(G-EQUAS)生物材料中全血铅的影响因素。方法:采用ICP-MS法对G-EQUAS全血铅进行测定,优化反应气体方式、样品稀释比、内标元素、同位素等,并对结果进行分析。结果:本研究表明,内标元素的选择、同位素、基质效应和物理效应可能影响ICP-MS测定生物样品中铅的准确性。结论:ICP-MS测定全血铅时避免了可能影响结果的因素。
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