Characteristics and Applications of Peptide Nucleic Acid in the Treatment of Infectious Diseases and the Effect of Antimicrobial Photodynamic Therapy on Treatment Effectiveness.

Q3 Pharmacology, Toxicology and Pharmaceutics Infectious disorders drug targets Pub Date : 2024-01-01 DOI:10.2174/1871526523666230724120957
Zahra Javanmard, Maryam Pourhajibagher, Abbas Bahador
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Abstract

Antibiotic resistance is a growing global problem, so there is an urgent need for new antimicrobial agents and strategies. Peptide nucleic acid (PNA) oligomers could be designed and utilized as gene-specific oligonucleotides to target any infectious agents. Selectivity and high-affinity binding are the main properties of PNA. However, in therapeutic applications, intracellular delivery of peptide nucleic acids is still a challenge. In photodynamic therapy (PDT), which could be a useful adjunct to mechanical and antibiotics in removing pathogenic agents, low-power lasers are used in appropriate wavelength for killing the microorganisms that have been treated with a photosensitizer drug. Antimicrobial photodynamic therapy (aPDT) in combination with lipid-charged nanoparticles of PNA is a promising alternative therapy proposed to control infectious diseases. This review summarizes progress in the uptake of peptide nucleic acids at intracellular targets. In addition, we focus on recent nanoparticle- based strategies to efficiently deliver conventional and chemically modified peptide nucleic acids. The likely impact of using two treatment methods simultaneously, i.e., PNP and PDT, has already been discussed.

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多肽核酸在治疗传染病中的特点和应用以及抗菌光动力疗法对治疗效果的影响。
抗生素耐药性是一个日益严重的全球性问题,因此迫切需要新的抗菌剂和策略。多肽核酸(PNA)寡聚体可被设计和用作基因特异性寡核苷酸,以靶向任何感染性病原体。选择性和高亲和性是 PNA 的主要特性。然而,在治疗应用中,多肽核酸的细胞内递送仍是一项挑战。在光动力疗法(PDT)中,使用适当波长的低功率激光来杀死经过光敏剂药物处理的微生物,可以作为机械和抗生素清除病原体的有效辅助手段。抗菌光动力疗法(aPDT)与带脂质的 PNA 纳米粒子相结合,是一种很有前景的控制传染病的替代疗法。本综述总结了肽核酸在细胞内靶点吸收方面的进展。此外,我们还重点介绍了最近基于纳米粒子的高效递送传统和化学修饰肽核酸的策略。我们已经讨论了同时使用两种治疗方法(即 PNP 和 PDT)可能产生的影响。
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来源期刊
Infectious disorders drug targets
Infectious disorders drug targets Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
3.10
自引率
0.00%
发文量
123
期刊介绍: Infectious Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in infectious disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in infectious disorders. As the discovery, identification, characterization and validation of novel human drug targets for anti-infective drug discovery continues to grow, this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.
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