Large for gestational age after frozen embryo transfer: an evaluation of the possible causes for this relationship

Rachel E. Gaume M.D. , Ryan J. Heitmann D.O. , Jacqueline Luizzi M.L.I.S., A.H.I.P. , Bruce D. Pier M.D.
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引用次数: 4

Abstract

Frozen embryo transfer is associated with increased fetal weight, increased rates of large for gestational age (LGA) infants, and increased macrosomia, when compared with fresh embryo transfer or natural conception. Although the incidence of LGA births after frozen embryo transfer has been stable for several years, the pathological causes for these findings are not understood. The purpose of this review is to understand the state of current literature suggesting causes for this relationship, and to highlight areas in need of future research to potentially address and correct this finding. Our review addresses finding in the area with respect to alterations in epigenetics, differing types of embryo culture media, differing days of cryopreservation, supraphysiologic estradiol levels, and with programmed versus natural cycle endometrial preparation.

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冷冻胚胎移植后胎龄大:对这种关系可能原因的评估
与新鲜胚胎移植或自然受孕相比,冷冻胚胎移植与胎儿体重增加、大胎龄婴儿(LGA)发生率增加和巨大儿增加有关。虽然冷冻胚胎移植后LGA出生的发生率已经稳定了好几年,但这些发现的病理原因尚不清楚。本综述的目的是了解当前文献的状态,提示这种关系的原因,并强调需要未来研究的领域,以潜在地解决和纠正这一发现。我们的综述涉及表观遗传学的改变,不同类型的胚胎培养基,不同的低温保存天数,生理上的雌二醇水平,以及程序与自然周期子宫内膜制备。
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来源期刊
F&S reviews
F&S reviews Endocrinology, Diabetes and Metabolism, Obstetrics, Gynecology and Women's Health, Urology
CiteScore
3.70
自引率
0.00%
发文量
0
审稿时长
61 days
期刊最新文献
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