Tumour-associated macrophages heterogeneity drives resistance to clinical therapy.

IF 4.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Expert Reviews in Molecular Medicine Pub Date : 2022-04-11 DOI:10.1017/erm.2022.8
Shuangshuang Guo, Xiaojing Chen, Chuhong Guo, Wei Wang
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引用次数: 9

Abstract

Tumour-associated macrophages (TAMs) constitute a plastic and heterogeneous cell population of the tumour microenvironment (TME) that can account for up to 50% of solid tumours. TAMs heterogeneous are associated with different cancer types and stages, different stimulation of bioactive molecules and different TME, which are crucial drivers of tumour progression, metastasis and resistance to therapy. In this context, understanding the sources and regulatory mechanisms of TAM heterogeneity and searching for novel therapies targeting TAM subpopulations are essential for future studies. In this review, we discuss emerging evidence highlighting the redefinition of TAM heterogeneity from three different directions: origins, phenotypes and functions. We notably focus on the causes and consequences of TAM heterogeneity which have implications for the evolution of therapeutic strategies that targeted the subpopulations of TAMs.

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肿瘤相关巨噬细胞的异质性导致对临床治疗的耐药性。
肿瘤相关巨噬细胞(tam)构成肿瘤微环境(TME)的可塑性和异质性细胞群,可占实体肿瘤的50%。tam的异质性与不同的癌症类型和分期、不同的生物活性分子刺激和不同的TME相关,这是肿瘤进展、转移和治疗耐药的关键驱动因素。在此背景下,了解TAM异质性的来源和调控机制,寻找针对TAM亚群的新疗法对未来的研究至关重要。在这篇综述中,我们从三个不同的方向讨论了强调TAM异质性重新定义的新证据:起源、表型和功能。我们特别关注TAM异质性的原因和后果,这对针对TAM亚群的治疗策略的发展具有重要意义。
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来源期刊
Expert Reviews in Molecular Medicine
Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
7.40
自引率
1.60%
发文量
45
期刊介绍: Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.
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