Treatment of experimentally induced partial-thickness burns in rats with different silver-impregnated dressings.

IF 1.1 4区医学 Q3 SURGERY Acta cirurgica brasileira Pub Date : 2022-01-01 DOI:10.1590/acb370801

Carolyna de Sousa Carvalho, Milton Junio Cândido Bernardes, Randys Caldeira Gonçalves, Marielle Sousa Vilela, Marcus Vinicius Meneses da Silva, Vinicius da Silva Oliveira, Marcelo Ribeiro da Rocha, Marina Clare Vinaud, Hélio Galdino Junio, Ruy de Souza Lino Junior

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引用次数: 1

Abstract

Purpose: To evaluate the morphometric, macroscopic and microscopic aspects of experimentally induced partial-thickness burns in rats treated with different silver-based dressings.

Methods: Wistar rats were used, divided into six treatments: saline (NaCl 0.9%); silver sulfadiazine 1%; Silvercel; Mepilex Ag; Aquacel Ag and Acticoat. The animals were monitored daily and euthanized at 7, 14 and 30 days after injury induction (DAI).

Results: At 7 DAI, necrosis/crust was greater in control, silver sulfadiazine and Mepilex Ag treatments, granulation tissue was induced by Aquacel Ag, polymorphonuclear infiltrate (PMN) infiltration was intensified by Mepilex Ag; mononuclear infiltrate (MN) infiltration and angiogenesis were increased by Silvercel. At 14 DAI, hemorrhage was decreased by Silvercel and Mepilex Ag, PMN infiltration increased by Acticoat. At 30 DAI, angiogenesis was greater in the Acticoat treatment and fibroblasts were increased by Acticoat and Mepilex Ag. Collagen was induced at 14 DAI by silver sulfadiazine and Aquacel Ag and, at 30 DAI, by silver sulfadiazine and Silvercel treatments.

Conclusions: Silvercel and Acticoat presented better results than the other products. However, all the dressings were better than the control at some point during the process, and may contribute to the healing of partial thickness burns. Silvercel and Aquacel Ag treatments induced better cosmetic outcomes regarding wound closure and scarring.

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不同浸银敷料对实验性大鼠局部烧伤的治疗作用。

目的:探讨不同银基敷料对大鼠实验性部分厚度烧伤的形态学、宏观和微观影响。方法:选用Wistar大鼠，分为生理盐水(NaCl 0.9%)处理;磺胺嘧啶银1%;Silvercel;Mepilex Ag);水产养殖Ag和活性涂层。每天监测动物，并在损伤诱导(DAI)后7、14和30天实施安乐死。结果:7 DAI时，对照组、磺胺嘧啶银组和Mepilex Ag组坏死/结皮更大，Aquacel Ag诱导肉芽组织形成，Mepilex Ag强化多形核浸润(PMN);单核浸润(MN)和血管生成增加。在DAI 14时，Silvercel和Mepilex Ag减少出血，Acticoat增加PMN浸润。在30 DAI时，Acticoat处理的血管生成更大，Acticoat和Mepilex Ag增加了成纤维细胞。在DAI 14时，磺胺嘧啶银和水产养殖银诱导胶原蛋白，在DAI 30时，磺胺嘧啶银和银细胞诱导胶原蛋白。结论:Silvercel和Acticoat具有较好的治疗效果。然而，所有敷料在治疗过程中的某些点上都优于对照组，这可能有助于部分厚度烧伤的愈合。Silvercel和Aquacel Ag治疗在伤口愈合和疤痕方面具有更好的美容效果。

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