Is Greenness Associated with Dementia? A Systematic Review and Dose-Response Meta-analysis.

IF 7.4 2区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Current Environmental Health Reports Pub Date : 2022-12-01 DOI:10.1007/s40572-022-00365-5

Federico Zagnoli, Tommaso Filippini, Marcia P Jimenez, Lauren A Wise, Elizabeth E Hatch, Marco Vinceti

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引用次数: 8

Abstract

Purpose of review: We assessed the relation between environmental greenness and risk of dementia and cognitive impairment, based on a systematic review and meta-analysis up to March 30, 2022, characterizing whenever possible the shape of the association using dose-response meta-analysis.

Recent findings: Twelve studies were included in this review, either using normalized difference vegetation index (NDVI) or land use/cover (LU/LC) methodology to assess greenness. Comparing the highest versus lowest exposure categories of greenness assessed using the NDVI (6 studies) or LU/LC (6 studies), we found no association with dementia. Dose-response meta-analysis of the association between greenness measured by LU/LC and dementia, based on only 3 studies, indicated a U-shaped association, but estimates were imprecise. Our systematic review and meta-analysis provided some evidence of a slight inverse association between greenness and dementia at intermediate exposure levels, but not at high levels. Potential methodological limitations, such as exposure misclassification and unmeasured confounding, may have affected the results.

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绿色与痴呆有关吗?系统评价和剂量-反应荟萃分析。

综述目的:我们基于一项截至2022年3月30日的系统综述和荟萃分析，评估了环境绿色度与痴呆和认知障碍风险之间的关系，并尽可能使用剂量-反应荟萃分析来表征这种关联的形态。最新发现:本综述包括12项研究，采用归一化植被指数(NDVI)或土地利用/覆盖(LU/LC)方法评估绿化。比较使用NDVI(6项研究)或LU/LC(6项研究)评估的最高和最低暴露度类别，我们发现与痴呆没有关联。仅基于3项研究，对LU/LC测量的绿度与痴呆之间的关联进行剂量-反应荟萃分析，显示u型关联，但估计不精确。我们的系统回顾和荟萃分析提供了一些证据，表明在中等暴露水平下，绿化和痴呆之间存在轻微的负相关关系，但在高暴露水平下则不然。潜在的方法学局限性，如暴露错误分类和未测量的混杂，可能影响结果。

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来源期刊

Current Environmental Health Reports Multiple-

CiteScore

13.60

自引率

1.30%

发文量

期刊介绍： Current Environmental Health Reports provides up-to-date expert reviews in environmental health. The goal is to evaluate and synthesize original research in all disciplines relevant for environmental health sciences, including basic research, clinical research, epidemiology, and environmental policy.