Sarah Boughdad, Michael Da Mota, Mélanie Mendes De Carvalho, Maria Firsova, John O Prior, Niklaus Schaefer
{"title":"Lymphopenia during <sup>177</sup>Lu-DOTATATE therapy leading to recurrence of tuberculosis: a case report.","authors":"Sarah Boughdad, Michael Da Mota, Mélanie Mendes De Carvalho, Maria Firsova, John O Prior, Niklaus Schaefer","doi":"10.1186/s41824-022-00157-y","DOIUrl":null,"url":null,"abstract":"<p><p>We report the case of a 72-year-old woman who presented with tuberculous arthritis during the setting of <sup>177</sup>Lu-DOTATATE therapy for a grade-2 neuro-endocrine pancreatic tumor with liver metastases. We hypothesized that this recurrence might have been related to the occurrence of lymphopenia, which is common during PRRT. Indeed, though lymphopenia is frequently dismissed, it could lead to the development of opportunistic diseases and its severity should be examined, especially in case of abnormal clinical symptoms.</p>","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":"6 1","pages":"36"},"PeriodicalIF":1.7000,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744994/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Hybrid Imaging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s41824-022-00157-y","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
We report the case of a 72-year-old woman who presented with tuberculous arthritis during the setting of 177Lu-DOTATATE therapy for a grade-2 neuro-endocrine pancreatic tumor with liver metastases. We hypothesized that this recurrence might have been related to the occurrence of lymphopenia, which is common during PRRT. Indeed, though lymphopenia is frequently dismissed, it could lead to the development of opportunistic diseases and its severity should be examined, especially in case of abnormal clinical symptoms.