Simultaneous Multifrequency (SiMFy) Stimulus: A Novel and Reliable Stimulus for Frequency Tuning of Ocular Vestibular-Evoked Myogenic Potentials.

Abstract

Background: Frequency tuning of ocular vestibular evoked myogenic potential (oVEMP) refers to the frequency of tone burst that produces the largest amplitude oVEMP. There is an ever-growing pool of published studies that found the frequency tuning of oVEMP distinctly different in Ménière's disease than the age-matched controls and benign paroxysmal positional vertigo. However, recording oVEMP in response to many frequencies makes an already lengthy vestibular test battery even more cumbersome and time-consuming.

Purpose: The aim of this study was to develop a novel time-saving stimulus that produces reliable results.

Research design: Prospective study.

Study sample: The study included 25 young, healthy adults.

Data collection: The tone-bursts of 2000, 1500, 1000, 750, 500, and 250 Hz were generated and sequenced in this order to prepare a stimulus for simultaneous multifrequency (SiMFy) oVEMP. The response parameters of SiMFy and conventional oVEMP methods were compared.

Results: No significant difference in peak-to-peak amplitude and frequency tuning existed between conventional and SiMFy oVEMP (p > 0.05). SiMFy had better test-retest reliability and was less time-consuming than the conventional oVEMP.

Conclusions: SiMFy is a time-saving and reliable stimulus for obtaining frequency tuning of oVEMP with no compromise on the outcomes. It can be immediately applied in most commercially available evoked potential systems with a facility for loading an external stimulus.