A novel polymer-free everolimus-eluting stent with a nitrogen-doped titanium dioxide film inhibits restenosis and thrombosis in a swine coronary model.

IF 2.5 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiology journal Pub Date : 2023-02-15 DOI:10.5603/CJ.a2023.0006
Dae Young Hyun, Xiongyi Han, Dae Sung Park, Munki Kim, Jun Kyu Park, Kyung Hoon Cho, Doo Sun Sim, Young Joon Hong, Youngkeun Ahn, Myung Ho Jeong
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Abstract

Background: Short-term outcomes regarding the safety and efficacy of a polymer-free everolimus-eluting stent (EES) with a nitrogen-doped titanium dioxide (N-TiO₂) film in a swine coronary model have been reported. However, the long-term results of the use of this type of stent have not yet been evaluated or compared to those of other polymer-free coronary stents. Therefore, this study aimed to determine the mid- to long-term safety and efficacy of a polymer-free EES with an N-TiO₂ film in a swine coronary model.

Methods: Polymer-free EES with N-TiO₂ films (n = 30) and polymer-free sirolimus-eluting stents (SES; n = 30) were implanted in 30 pigs. Quantitative coronary analysis and optical coherence tomography were conducted immediately and at 1 (quantitative coronary analysis only), 3, and 6 months after stenting. Histopathologic examinations were performed at 1, 3, and 6 months after stenting.

Results: The polymer-free EES group had a lower percentage of neointimal growth than the polymer-free SES group at 3 months (22.5% ± 11.4% vs. 32.1% ± 12.3%; p < 0.001). The polymer-free EES group had a lower fibrin score than the polymer-free SES group at 1 month (1.9 ± 0.45 vs. 2.5 ± 0.54; p = 0.001). The re-endothelialization rates were similar between groups. The polymer-free EES group had a lower percentage of the area of stenosis than the polymer-free SES group throughout the follow-up period.

Conclusions: The novel polymer-free EES with an N-TiO₂ film has superior safety and efficacy than the polymer-free SES at the 6-month follow-up in a swine model.

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带有掺氮二氧化钛薄膜的新型无聚合物依维莫司洗脱支架可抑制猪冠状动脉模型中的再狭窄和血栓形成。
背景:有报道称,在猪冠状动脉模型中使用了不含聚合物的依维莫司洗脱支架(EES),其安全性和有效性均达到了短期效果,该支架带有掺氮二氧化钛(N-TiO₂)薄膜。然而,尚未对使用这种支架的长期效果进行评估,也未将其与其他不含聚合物的冠状动脉支架进行比较。因此,本研究旨在确定带有 N-TiO₂ 膜的无聚合物 EES 在猪冠状动脉模型中的中长期安全性和有效性:方法:在30头猪体内植入了带有N-TiO₂薄膜的无聚合物EES(n = 30)和无聚合物西罗莫司洗脱支架(SES;n = 30)。在支架植入后立即、1 个月(仅定量冠状动脉分析)、3 个月和 6 个月进行了定量冠状动脉分析和光学相干断层扫描。支架植入后 1、3 和 6 个月进行组织病理学检查:结果:3 个月时,不含聚合物的 EES 组的新生内膜生长比例低于不含聚合物的 SES 组(22.5% ± 11.4% 对 32.1% ± 12.3%;P < 0.001)。1 个月时,无聚合物 EES 组的纤维蛋白评分低于无聚合物 SES 组(1.9 ± 0.45 vs. 2.5 ± 0.54;p = 0.001)。各组的再内皮化率相似。在整个随访期间,无聚合物 EES 组的狭窄面积百分比低于无聚合物 SES 组:结论:在猪模型中,随访 6 个月后,带有 N-TiO₂ 膜的新型无聚合物 EES 的安全性和有效性优于无聚合物 SES。
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来源期刊
Cardiology journal
Cardiology journal CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
5.10
自引率
10.30%
发文量
188
审稿时长
4-8 weeks
期刊介绍: Cardiology Journal is a scientific, peer-reviewed journal covering a broad spectrum of topics in cardiology. The journal has been published since 1994 and over the years it has become an internationally recognized journal of cardiological and medical community. Cardiology Journal is the journal for practicing cardiologists, researchers, and young trainees benefiting from broad spectrum of useful educational content.
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