Tongue and Lip Acceleration as a Measure of Speech Decline in Amyotrophic Lateral Sclerosis.

IF 1.1 4区 医学 Q3 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY Folia Phoniatrica et Logopaedica Pub Date : 2023-01-01 Epub Date: 2022-06-27 DOI:10.1159/000525514
Kristin J Teplansky, Alan Wisler, Jordan R Green, Thomas Campbell, Daragh Heitzman, Sara G Austin, Jun Wang
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引用次数: 1

Abstract

Purpose: The goal of this study was to examine the efficacy of acceleration-based articulatory measures in characterizing the decline in speech motor control due to amyotrophic lateral sclerosis (ALS).

Method: Electromagnetic articulography was used to record tongue and lip movements during the production of 20 phrases. Data were collected from 50 individuals diagnosed with ALS. Articulatory kinematic variability was measured using the spatiotemporal index of both instantaneous acceleration and speed signals. Linear regression models were used to analyze the relationship between variability measures and intelligible speaking rate (a clinical measure of disease progression). A machine learning algorithm (support vector regression, SVR) was used to assess whether acceleration or speed features (e.g., mean, median, maximum) showed better performance at predicting speech severity in patients with ALS.

Results: As intelligible speaking rate declined, the variability of acceleration of tongue and lip movement patterns significantly increased (p < 0.001). The variability of speed and vertical displacement did not significantly predict speech performance measures. Additionally, based on R2 and root mean square error (RMSE) values, the SVR model was able to predict speech severity more accurately from acceleration features (R2 = 0.601, RMSE = 38.453) and displacement features (R2 = 0.218, RMSE = 52.700) than from speed features (R2 = 0.554, RMSE = 40.772).

Conclusion: Results from these models highlight differences in speech motor control in participants with ALS. The variability in acceleration of tongue and lip movements increases as speech performance declines, potentially reflecting physiological deviations due to the progression of ALS. Our findings suggest that acceleration is a more sensitive indicator of speech deterioration due to ALS than displacement and speed and may contribute to improved algorithm designs for monitoring disease progression from speech signals.

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用舌头和嘴唇的加速度来衡量肌萎缩侧索硬化症患者的语言能力衰退程度。
目的:本研究旨在探讨基于加速度的发音测量方法在描述肌萎缩性脊髓侧索硬化症(ALS)导致的言语运动控制能力下降方面的效果:方法:使用电磁发音法记录 20 个短语发音过程中舌头和嘴唇的运动。数据收集自 50 名确诊为 ALS 的患者。使用瞬时加速度和速度信号的时空指数测量发音运动变异性。线性回归模型用于分析变异性测量与可理解说话率(疾病进展的临床测量指标)之间的关系。使用机器学习算法(支持向量回归,SVR)来评估加速度或速度特征(如平均值、中位数、最大值)在预测 ALS 患者言语严重程度方面是否表现更佳:随着可理解说话率的下降,舌头和嘴唇运动模式的加速度变异性显著增加(p < 0.001)。速度和垂直位移的变异性对语言表达能力的预测并不明显。此外,根据 R2 和均方根误差 (RMSE) 值,SVR 模型能够根据加速度特征(R2 = 0.601,RMSE = 38.453)和位移特征(R2 = 0.218,RMSE = 52.700)比根据速度特征(R2 = 0.554,RMSE = 40.772)更准确地预测语音严重程度:这些模型的结果突显了 ALS 患者在言语运动控制方面的差异。随着语言能力的下降,舌头和嘴唇运动加速度的变异性也在增加,这可能反映了 ALS 进展过程中的生理偏差。我们的研究结果表明,与位移和速度相比,加速度是反映 ALS 引起的言语退化的一个更灵敏的指标,可能有助于改进通过言语信号监测疾病进展的算法设计。
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来源期刊
Folia Phoniatrica et Logopaedica
Folia Phoniatrica et Logopaedica AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY-OTORHINOLARYNGOLOGY
CiteScore
2.30
自引率
10.00%
发文量
28
审稿时长
>12 weeks
期刊介绍: Published since 1947, ''Folia Phoniatrica et Logopaedica'' provides a forum for international research on the anatomy, physiology, and pathology of structures of the speech, language, and hearing mechanisms. Original papers published in this journal report new findings on basic function, assessment, management, and test development in communication sciences and disorders, as well as experiments designed to test specific theories of speech, language, and hearing function. Review papers of high quality are also welcomed.
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