Clinical proteomics towards multiomics in cancer.

IF 6.9 2区 化学 Q1 SPECTROSCOPY Mass Spectrometry Reviews Pub Date : 2022-12-10 DOI:10.1002/mas.21827
Chad J Creighton
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Abstract

Recent technological advancements in mass spectrometry (MS)-based proteomics technologies have accelerated its application to study greater and greater numbers of human tumor specimens. Over the last several years, the Clinical Proteomic Tumor Analysis Consortium, the International Cancer Proteogenome Consortium, and others have generated MS-based proteomic profiling data combined with corresponding multiomics data on thousands of human tumors to date. Proteomic data sets in the public domain can be re-examined by other researchers with different questions in mind from what the original studies explored. In this review, we examine the increasing role of proteomics in studying cancer, along with the potential for previous studies and their associated data sets to contribute to improving the diagnosis and treatment of cancer in the clinical setting. We also explore publicly available proteomics and multi-omics data from cancer cell line models to show how such data may aid in identifying therapeutic strategies for cancer subsets.

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临床蛋白质组学走向癌症多组学。
基于质谱(MS)的蛋白质组学技术的最新技术进步加速了其在越来越多的人类肿瘤标本研究中的应用。在过去几年中,临床肿瘤蛋白质组分析联盟(Clinical Proteomic Tumor Analysis Consortium)、国际癌症蛋白质基因组联盟(International Cancer Proteogenome Consortium)和其他组织已经生成了基于质谱的蛋白质组分析数据以及相应的多组学数据,这些数据迄今已涉及数千例人类肿瘤。其他研究人员可以带着与原始研究不同的问题,对公共领域的蛋白质组数据集进行重新研究。在这篇综述中,我们将探讨蛋白质组学在癌症研究中日益重要的作用,以及以前的研究及其相关数据集在改善临床癌症诊断和治疗方面的潜力。我们还探讨了来自癌症细胞系模型的公开蛋白质组学和多组学数据,以说明这些数据如何有助于确定癌症亚群的治疗策略。
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来源期刊
Mass Spectrometry Reviews
Mass Spectrometry Reviews 物理-光谱学
CiteScore
16.30
自引率
3.00%
发文量
56
期刊介绍: The aim of the journal Mass Spectrometry Reviews is to publish well-written reviews in selected topics in the various sub-fields of mass spectrometry as a means to summarize the research that has been performed in that area, to focus attention of other researchers, to critically review the published material, and to stimulate further research in that area. The scope of the published reviews include, but are not limited to topics, such as theoretical treatments, instrumental design, ionization methods, analyzers, detectors, application to the qualitative and quantitative analysis of various compounds or elements, basic ion chemistry and structure studies, ion energetic studies, and studies on biomolecules, polymers, etc.
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