Broad spectrum antiviral nucleosides-Our best hope for the future.

4区 化学 Q3 Chemistry Annual Reports in Medicinal Chemistry Pub Date : 2021-01-01 DOI:10.1016/bs.armc.2021.09.001
Katherine L Seley-Radtke, Joy E Thames, Charles D Waters
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引用次数: 8

Abstract

The current focus for many researchers has turned to the development of therapeutics that have the potential for serving as broad-spectrum inhibitors that can target numerous viruses, both within a particular family, as well as to span across multiple viral families. This will allow us to build an arsenal of therapeutics that could be used for the next outbreak. In that regard, nucleosides have served as the cornerstone for antiviral therapy for many decades. As detailed herein, many nucleosides have been shown to inhibit multiple viruses due to the conserved nature of many viral enzyme binding sites. Thus, it is somewhat surprising that up until very recently, many researchers focused more on "one bug one drug," rather than trying to target multiple viruses given those similarities. This attitude is now changing due to the realization that we need to be proactive rather than reactive when it comes to combating emerging and reemerging infectious diseases. A brief summary of prominent nucleoside analogues that previously exhibited broad-spectrum activity and are now under renewed interest, as well as new analogues, that are currently under investigation against SARS-CoV-2 and other viruses is discussed herein.

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广谱抗病毒核苷——我们对未来的最大希望。
目前,许多研究人员的重点已转向开发具有广谱抑制剂潜力的治疗方法,这种抑制剂可以针对特定家族中的许多病毒,也可以跨越多个病毒家族。这将使我们能够建立一个可用于下一次疫情爆发的治疗药物库。在这方面,核苷几十年来一直是抗病毒治疗的基石。正如本文所详述的,由于许多病毒酶结合位点的保守性,许多核苷已被证明可以抑制多种病毒。因此,令人惊讶的是,直到最近,许多研究人员更多地关注“一种病毒一种药物”,而不是试图针对多种病毒,因为这些相似之处。这种态度现在正在改变,因为我们认识到,在防治新出现和再出现的传染病方面,我们需要积极主动,而不是被动被动。本文简要总结了以前表现出广谱活性的突出核苷类似物,现在重新引起了人们的兴趣,以及目前正在研究的针对SARS-CoV-2和其他病毒的新类似物。
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来源期刊
CiteScore
5.70
自引率
0.00%
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0
审稿时长
>12 weeks
期刊介绍: Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry with an emphasis on emerging topics in the biological sciences that are expected to provide the basis for entirely new future therapies.
期刊最新文献
The challenges and opportunities of developing small molecule inhibitors of MraY. Preface Anno 2021: Which antivirals for the coming decade? Improving properties of the nucleobase analogs T-705/T-1105 as potential antiviral. Broad spectrum antiviral nucleosides-Our best hope for the future.
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