Nickel-Catalyzed Radical Ring-Opening Phosphorylation of Cycloalkyl Hydroperoxides Leading to Distal Acylphosphine Oxides

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC Organic Letters Pub Date : 2023-02-02 DOI:10.1021/acs.orglett.2c04233

Yue Ying, Ziyi Ye, An Wang, Xingjie Chen, Shanshan Meng, Pengxiang Xu*, Yuxing Gao* and Yufen Zhao,

引用次数: 1

Abstract

A facile and efficient nickel-catalyzed C–C bond cleavage/phosphorylation of various cycloalkyl hydroperoxides was developed. This radical ring-opening strategy provided practical access to structurally diverse distal ketophosphine oxides in one pot through concurrent C═O/C–P bond formation with high atom economy under mild room temperature and base-free conditions.

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镍催化环烷基氢过氧化物自由基开环磷酸化生成远端酰基膦氧化物

研究了一种简便高效的镍催化各种环烷基氢过氧化物C-C键裂解/磷酸化反应。这种自由基开环策略在室温和无碱条件下，通过同时形成C = O/C - p键，在一个锅中获得结构多样的远端酮膦氧化物，具有高原子经济性。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.