Molecular Targets of Shenqi Dihuang, A Traditional Chinese Herbal Medicine, and Its Potential Role in Renal Cell Carcinoma Therapy.

IF 1.4 4区生物学 Q4 GENETICS & HEREDITY Genetics research Pub Date : 2023-01-01 DOI:10.1155/2023/2355891

Xinglin Chen, Tongtong Zhang, Xiangyang Zhan, Xinyue Zang, Xinyu Zhai, Zhong Wan, Minyao Ge, Mingyue Tan, Jianyi Gu, Dongliang Xu

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Abstract

Chinese herbal medicine (CHM), which includes herbal slices and proprietary products, is widely used in China. Shenqi Dihuang (SQDH) is a traditional Chinese medicine (TCM) formula with ingredients that affect tumor growth. Despite recent advances in prognosis, patients with renal cell carcinoma (RCC) cannot currently receive curative treatment. The present study aimed to explore the potential target genes closely associated with SQDH. The gene expression data for SQDH and RCC were obtained from the TCMSP and TCGA databases. The SQDH-based prognostic prediction model reveals a strong correlation between RCC and SQDH. In addition, the immune cell infiltration analysis indicated that SQDH might be associated with the immune response of RCC patients. Based on this, we successfully built the prognostic prediction model using SQDH-related genes. The results demonstrated that CCND1 and NR3C2 are closely associated with the prognosis of RCC patients. Finally, the pathways enrichment analysis revealed that response to oxidative stress, cyclin binding, programmed cell death, and immune response are the most enriched pathways in CCND1. Furthermore, transcription regulator activity, regulation of cell population proliferation, and cyclin binding are closely associated with the NR3C2.

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中药参芪地黄的分子靶点及其在肾癌治疗中的潜在作用

中草药(CHM)包括草药片和专有产品，在中国被广泛使用。参芪地黄(SQDH)是一种中药配方，含有影响肿瘤生长的成分。尽管最近在预后方面取得了进展，但肾细胞癌(RCC)患者目前仍无法获得治愈性治疗。本研究旨在探索与SQDH密切相关的潜在靶基因。SQDH和RCC的基因表达数据来自TCMSP和TCGA数据库。基于SQDH的预后预测模型显示RCC与SQDH有很强的相关性。此外，免疫细胞浸润分析提示SQDH可能与RCC患者的免疫应答有关。在此基础上，我们成功构建了sqdh相关基因的预后预测模型。结果表明，CCND1和NR3C2与RCC患者的预后密切相关。最后，通路富集分析显示，氧化应激应答、细胞周期蛋白结合、程序性细胞死亡和免疫应答是CCND1中富集最多的通路。此外，转录调控因子活性、细胞群体增殖调控和细胞周期蛋白结合与NR3C2密切相关。

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来源期刊

Genetics research 生物-遗传学

自引率

6.70%

发文量

审稿时长

>12 weeks

期刊介绍： Genetics Research is a key forum for original research on all aspects of human and animal genetics, reporting key findings on genomes, genes, mutations and molecular interactions, extending out to developmental, evolutionary, and population genetics as well as ethical, legal and social aspects. Our aim is to lead to a better understanding of genetic processes in health and disease. The journal focuses on the use of new technologies, such as next generation sequencing together with bioinformatics analysis, to produce increasingly detailed views of how genes function in tissues and how these genes perform, individually or collectively, in normal development and disease aetiology. The journal publishes original work, review articles, short papers, computational studies, and novel methods and techniques in research covering humans and well-established genetic organisms. Key subject areas include medical genetics, genomics, human evolutionary and population genetics, bioinformatics, genetics of complex traits, molecular and developmental genetics, Evo-Devo, quantitative and statistical genetics, behavioural genetics and environmental genetics. The breadth and quality of research make the journal an invaluable resource for medical geneticists, molecular biologists, bioinformaticians and researchers involved in genetic basis of diseases, evolutionary and developmental studies.