Proprioception: A New Era Set in Motion by Emerging Genetic and Bionic Strategies?

IF 15.7 1区 医学 Q1 PHYSIOLOGY Annual review of physiology Pub Date : 2023-02-10 Epub Date: 2022-11-18 DOI:10.1146/annurev-physiol-040122-081302
Paul D Marasco, Joriene C de Nooij
{"title":"Proprioception: A New Era Set in Motion by Emerging Genetic and Bionic Strategies?","authors":"Paul D Marasco, Joriene C de Nooij","doi":"10.1146/annurev-physiol-040122-081302","DOIUrl":null,"url":null,"abstract":"<p><p>The generation of an internal body model and its continuous update is essential in sensorimotor control. Although known to rely on proprioceptive sensory feedback, the underlying mechanism that transforms this sensory feedback into a dynamic body percept remains poorly understood. However, advances in the development of genetic tools for proprioceptive circuit elements, including the sensory receptors, are beginning to offer new and unprecedented leverage to dissect the central pathways responsible for proprioceptive encoding. Simultaneously, new data derived through emerging bionic neural machine-interface technologies reveal clues regarding the relative importance of kinesthetic sensory feedback and insights into the functional proprioceptive substrates that underlie natural motor behaviors.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":"85 ","pages":"1-24"},"PeriodicalIF":15.7000,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10810321/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual review of physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1146/annurev-physiol-040122-081302","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/11/18 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

The generation of an internal body model and its continuous update is essential in sensorimotor control. Although known to rely on proprioceptive sensory feedback, the underlying mechanism that transforms this sensory feedback into a dynamic body percept remains poorly understood. However, advances in the development of genetic tools for proprioceptive circuit elements, including the sensory receptors, are beginning to offer new and unprecedented leverage to dissect the central pathways responsible for proprioceptive encoding. Simultaneously, new data derived through emerging bionic neural machine-interface technologies reveal clues regarding the relative importance of kinesthetic sensory feedback and insights into the functional proprioceptive substrates that underlie natural motor behaviors.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
直觉:新出现的遗传和仿生策略开启了一个新时代?
内部身体模型的生成和持续更新对感觉运动控制至关重要。尽管已知本体感觉依赖于本体感觉反馈,但将这种感觉反馈转化为动态身体知觉的内在机制仍然鲜为人知。然而,针对本体感觉电路元件(包括感觉受体)的基因工具的开发进展开始为剖析本体感觉编码的中心通路提供前所未有的新手段。与此同时,通过新兴仿生神经机器接口技术获得的新数据揭示了运动感觉反馈相对重要性的线索,并揭示了支撑自然运动行为的本体感觉功能基底。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Annual review of physiology
Annual review of physiology 医学-生理学
CiteScore
35.60
自引率
0.00%
发文量
41
期刊介绍: Since 1939, the Annual Review of Physiology has been highlighting significant developments in animal physiology. The journal covers diverse areas, including cardiovascular physiology, cell physiology, ecological, evolutionary, and comparative physiology, endocrinology, gastrointestinal physiology, neurophysiology, renal and electrolyte physiology, respiratory physiology, and special topics.
期刊最新文献
From Muscle-Based Nonshivering Thermogenesis to Malignant Hyperthermia in Mammals. Inositol 1,4,5-Trisphosphate Receptor Mutations Associated with Human Disease: Insights into Receptor Function and Dysfunction. Sex, Gender, and COPD. Store-Operated Calcium Channels in the Nervous System. A Mechanistic Rationale for Incretin-Based Therapeutics in the Management of Obesity.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1